Thursday, March 31, 2022

Smoking Toad



I generally try to keep my research and posts confined to medical and scientific journals for a couple of reasons. First and foremost is that well documented bias against psychiatrists and whatever version of monolithic psychiatry that authors and editors in the popular media choose to embrace. Secondly, the information content of professional journals is much higher and the theories and concepts are what I have been studying for decades at this point. For the purpose of this post, I am making an exception and will be writing about a story from the New Yorker about hallucinogens (1).

Being child of the 1970s and a psychiatrist starting a short time later, I have had plenty of academic and professional experience with hallucinogens.  Given that experience, I am very skeptical about how the new wave of hallucinogens have been portrayed as a panacea for psychiatric problems.  Even more problematic is the portrayal that these compounds are generally well tolerated and have no significant adverse effects. I will be the first to acknowledge that there is a selection bias. People don’t end up coming to see me because they had a good experience with hallucinogens. They see me because they had a very bad experience and that is generally severe anxiety, panic attacks, and hallucinogen persisting perceptual disorder (HPPD). HPPD is a permanent change in perception after exposure to hallucinogens.  That can range from looking down and seeing the carpet moving continuously to noticing that there are trailers streaming from objects moving across your visual field.

If you research HPPD or hallucinogen side effects – relatively little turns up in the medical literature. There are probably less than 100 papers written on HPPD since the 1960s.  They are typical case reports, anecdotal treatment, and a call for more research on treatment. A major LSD study documenting disability had to wait until recently for an analysis of side effects.  I contacted 2 current hallucinogen researchers and asked them for a copy of the consent form they are using for their research projects in order to see what adverse effects their were advising their patients about. That was two years ago and I have yet to receive a reply. It is against this backdrop that I am going to present some concerns noted in the New Yorker article. 

The bulk of the story involves a trained Mexican physician who first gained some fame in 2013 when he gave a testimonial about overcoming crack cocaine addiction by using a psychedelic produced by the Sonoran Desert ToadIncilius alvarius.  This toad is in the family of true toads or Bufonidae and that may be why the toad is also referred to as Bufo alvarius using an incorrect genus name.  The Sonoran Desert extends through southern Arizona and California and along either side of the Gulf of California down the Baja Peninsula on the West and contiguous Mexico on the East.  This toad secretes a toxin to protect against predators.  The article points out that dogs have died as a result of this toxin. The toxin has been analyzed and it contains 5-methoxy DMT – the psychedelic claimed to treat the addiction. Since the research literature uses the abbreviation 5-MeO-DMT that is how I will refer to this compound. The usual superlatives are used to describe the psychedelic experience. Endorsements from celebrities are there endorsing the spread of toad medicine around the world.  The actual experience is described in eerie terms like: “completely dissolves reality as we know it” or “terror and a sense of ego dissolution” followed by what is described by uncertainty over what happened along the way.  I have abstracted the side effects listed in this article in the table below.

5-MeO-DMT Adverse Effects

General

Pain

Shortness of breath

Cardiovascular

High blood pressure

Tachycardia

Neuropsychiatric

Flashbacks

Extreme anxiety

Hyperventilation

Insomnia

 

Intoxication

Agitation

Aggressive behavior

Vomiting

Death

The article lists about 6 deaths that occurred while smoking 5-MeO-DMT – one of these deaths was attributed to anaphylaxis

 The main focus of the article is a single practitioner who is described as actively promoting this treatment and at the same time is considered problematic for inadequate monitoring of the patients he treats with 5-MeO-DMT. Doses are approximate, patient monitoring is lax to non-existent, and he has run into some legal problems, problems with practitioners of ethnic medicine, cultural problems with a local tribe, and ecological problems due to toad depletion.  Against that backdrop are the usual testimonials that  5-MeO-DMT has cured intractable substance use problems and psychiatric disorders like depression and PTSD. There are also examples of substance use problems getting worse to the point of a fatality and the whole experience of causing PTSD as well as alleviating it. Expert opinion is included with the usual qualifiers about how clinical trials might provide clearer answers and venture capital funding being available for depression trials.  

After reading the New Yorker article I went to ClinincalTrials.gov and found 5 5-MeO-DMT current studies listed.  Three appeared to be safety studies in normal volunteers and one of these studies was a dose ranging study. There was another study for treatment of depression. Three studies were completed with no results available.  The fifth study was not yet recruiting subjects. 

By way of contrast, I thought I would look at a paper that surveyed subjects who had taken 5-MeO-DMT (3) at least once especially for the side effect profile.  This study used an anonymous Internet survey to look retrospectively at the epidemiological features of people who have used this compound. The study design is limiting in this case because it likely screens for people who have had positive experiences and in this case may be motivated to promote psychedelics (the incentive for subjects was a very modest donation to an organization that promoted the study and use of psychedelics. The researchers collected demographic data, data on 5-MeO-DMT and other substances used, patterns of use and the effects of use (Mystical Experiences Questionnaire/MEQ) (4) and possible side effects through the Challenging Experiences Questionnaire/CEQ (5) that was apparently designed to study the challenging experiences associated with taking hallucinogens. I encourage reading the entire paper for all of the details. The final version of the CEQ is 26 items that have been factor analyzed to measure fear, grief, physical distress, insanity (fear of losing one’s mind on a sustained basis), isolation, death, and paranoia.

The authors basically conclude that users of 5-MeO-DMT do in fact experience mystical experiences per the MEQ.  The MEQ was originally studied for hallucinogen experiences and the specific questions can be found in reference 4 as well as the body of reference 3. It is probably not surprising that a hallucinogen creates a mystical experience.  The poll here suggests that it may be more intense than the subjects experienced with other hallucinogens. At one point in the paper the authors suggest that the mystical experience is thought to be curative, but that is really unclear at this point. If it is true, the duration of the cure is also unclear. From the New Yorker article there were testimonials that 5-MeO-DMT was useful for substance use and some other psychiatric disorders – but there was also a question of worsening.

Although this was not a clinical trial, medical literature typically describes adverse effects or adverse drug effects (ADEs) from any medical intervention used to elicit a specific therapeutic effect.  Those ADE checklists are used to assess safety as well as producing the warning and side effect literature for the package insert of approved medications.  The literature on psychedelics seems to have taken the direction that the focus should be on what are described as psychological effects (see second column in the following table under neuropsychiatric side effects). This is problematic because it seems to assumes that discrete bodily systems (other than the brain and perhaps the heart) are not involved with potential drug related side effects. The term side effects and adverse effects tend to be avoided other than to say that some people may have an adverse effect from the psychedelic experience. The New Yorker article and even the survey of 5-MeO-DMT users suggests that medical safety is a potential concern and that no matter what the setting a person needs to be carefully monitored after ingestion of this drug.  

5-MeO-DMT Adverse Effects (References 3,4,5)

General

Pain

Shortness of breath

Nausea

Cardiovascular

High blood pressure

Tachycardia

Neuropsychiatric

Flashbacks

Extreme anxiety

Hyperventilation

Insomnia

Fear

Hallucinations

Dissociation

 

Depersonalization

Aggression

Violence

Confusion

Paranoia

Grief

Insanity

Isolation

Death

Paranoia

Intoxication

No clear distinction

Other

 

 

A reasonable summary of what is known about currently known this drug at this point is that it is a powerful hallucinogen. The safety and efficacy of this drug is currently unknown. Caution is required in looking at a survey study where the primary interest in taking the drug is wanting a mystical experience and treatment of a psychiatric disorder is a secondary effect and yet the psychiatric disorder tends to improve.  The New Yorker article is a cautionary tale and a counterpoint to a lot of the hype around hallucinogens right now that includes travelling to a foreign spa and having it administered by a self-proclaimed guru. The deaths mentioned in that article and some places in the literature are another red flag in contrast to the universal proclamations about hallucinogen safety. People with complications and severe outcomes don’t generally participate in surveys – therefore surveys are not the best ways to determine how a toad toxin can be used on a therapeutic basis.

It always seems to come back to controlled randomized clinical trials that are carefully optimized for patient safety. I have been the medical person responsible for the safety of patients in many of these trials and that typically involves weekly visits with physical examinations and any indicated labs.  It is a tedious and expensive process and there are no good short cuts. Until then I advise extreme caution with hallucinogens or psychedelics. It is always good to keep in mind that human biology varies greatly. What some people tolerate without a problem for years can cause severe side effects or even death for others. I expect that will eventually be documented for hallucinogens.  

 

George Dawson, MD, DFAPA


Supplementary 1:  For past links to posts here on hallucinogens please see the following:

Are Hallucinogens the New Miracle Drugs:  https://real-psychiatry.blogspot.com/2016/06/are-hallucinogens-new-miracle-drugs.html

JWH Compounds Make the NEJM:  https://real-psychiatry.blogspot.com/2017/01/jwh-compounds-make-nejm.html


Supplementary 2:  I am always looking for suggestions on how to improve this blog. I have considered a post that is basically a primer on hallucinogens and psychedelics. Let me know if you are interested or if there is anything that I can write about this general topic that you might be interested in. It is probably obvious that I am a skeptic about all of the hype suggesting that hallucinogens/psychedelics are the new miracle drugs. 


References:

1: De Greef K. Toad Smoke. New Yorker. 2022 Mar 28: 38-45.

2: Larsen JK. Neurotoxicity and LSD treatment: a follow-up study of 151 patients in Denmark. Hist Psychiatry. 2016 Jun;27(2):172-89. doi: 10.1177/0957154X16629902. Epub 2016 Mar 10. PMID: 26966135.

Revisits the Danish LSD Study and concludes that “Most of the patients suffered from severe side effects of the LSD treatment many years afterwards.”

3: Reckweg JT, Uthaug MV, Szabo A, Davis AK, Lancelotta R, Mason NL, Ramaekers JG. The clinical pharmacology and potential therapeutic applications of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT). J Neurochem. 2022 Feb 11. doi: 10.1111/jnc.15587. Epub ahead of print. PMID: 35149998.

4:  Maclean KA, Leoutsakos JM, Johnson MW, Griffiths RR. Factor Analysis of the Mystical Experience Questionnaire: A Study of Experiences Occasioned by the Hallucinogen Psilocybin. J Sci Study Relig. 2012 Dec;51(4):721-737. doi: 10.1111/j.1468-5906.2012.01685.x. PMID: 23316089; PMCID: PMC3539773.

5:  Barrett FS, Bradstreet MP, Leoutsakos JS, Johnson MW, Griffiths RR. The Challenging Experience Questionnaire: Characterization of challenging experiences with psilocybin mushrooms. J Psychopharmacol. 2016 Dec;30(12):1279-1295. doi: 10.1177/0269881116678781. Epub 2016 Nov 17. PMID: 27856683; PMCID: PMC5549781.

“…challenging psychological experiences during the acute effects of psychedelics are not uncommon.”  p. 1279

6:  Murdaugh LB.  Adverse drug reaction reporting. In: Competence Assessment Tools. 2015. American Society of Health-System Pharmacists.  Bethesda, MD.  Accessed Online:  https://doi.org/10.37573/9781585284030.040

 

 

 

Monday, March 21, 2022

Prolonged Grief Disorder - A Few Comments



The New York Times came out with an article on prolonged grief disorder.  I thought I would write about it because in some ways it is a continuation of the criticism that started with the DSM-5 release in 2015.  The response to that piece is one of the most read articles on thisblog. As I pointed out in that article and several since, the release of the DSM-5 has been a predicted non-event. There were no scandalous developments based on releasing a document that hardly anyone reads and is not even owned by most of the people who prescribe medications for psychiatric indications – primary care physicians.

The new piece based on the release of DSM5-TR is much more balanced.  A well-known psychiatric researcher Katherine Shear, MD is quoted as well as an epidemiologist Holly Prigerson, PhD who discovered data supportive of the diagnosis and studied the reliability and validity.  Paul Appelbaum, MD is the head of the committee to include new diagnoses in the manual and he also explains the rationale.

What did I not like about the article?  It starts out with the old saw about how the DSM 5 is sometimes known as psychiatry’s bible. I appreciate the qualifier but let’s lose the term bible in any reference to the DSM.  That descriptor is wrong at several levels – the most important one being that it is a classification system.  Please refer to it as psychiatry’s phone book or catalogue from now on, even though it is nowhere near as accurate as a phone book or any commercial catalogue.

The author goes on to describe the inclusion of prolonged grief disorder into the latest revision of DSM as controversial and then collects opinions on either side of what I consider to be an imaginary controversy. Why am I so bold to call this controversy imaginary?  Maybe it is not entirely imaginary, but it certainly is not as big a deal as it is portrayed in the article and here is why.

The first argument is that including it in the DSM means that professionals can now bill for it. In fact, all hospitals, clinics, public payers, and insurance companies require ICD-11 codes and not DSM codes.  Granted, the DSM codes are typically coordinated to match ICD-11 codes but there is not a perfect match.  ICD-11 codes are available for free and do not require a copy of the DSM 5 TR. The diagnosis of prolonged grief disorder was included in the ICD-11 in 2020 (2) and it is easier to make the diagnosis.  Quoting from reference 2:

“To meet PGDICD-11 criteria one needs to experience persistent and pervasive longing for the deceased and/or persistent and pervasive cognitive preoccupation with the deceased, combined with any of 10 additional grief reactions assumed indicative of intense emotional pain for at least six months after bereavement. Contrary to the 5th revision of the Diagnostical and Statistical Manual of Mental Disorders [DSM-5; (11)] and the 10th revision of the International Classification of Diseases [ICD-10; (12)], the ICD-11 only uses a typological approach, implying that diagnosis descriptions are simple and there is no strict requirement for the number of symptoms one needs to experience to meet the diagnostic threshold.”

The insurance company billing is further complicated by the fact that there are many other current diagnoses that can be used to treat a person severely incapacitated over a prolonged or severe course of grief.  Per my original blog Paula Clayton, MD explained this 45 years ago based on her research that also showed a small percentage of people become depressed during grief and require treatment. A prolonged grief disorder (PGD) diagnoses is not necessary and, in some cases, may lead to problems with insurance companies. It is well known that some insurance companies will not reimburse for some diagnoses that they think do not require treatment by a mental health provider. What they think of a PGD diagnosis is unknown at this time.

The second argument is that it may lead to biological treatments for the disorder. They cite a naltrexone trial for this disorder. Let me be the first to predict that the naltrexone will probably not work but I will also point out it is a medication that could be prescribed right now without putting PGD in the DSM 5 TR. The author states this may set off a competition among pharmaceutical companies for effective medications. That may be true – but what will the likely outcome be?  We already know that many people with PGD actually have treatable depression and respond to conventional treatments. We also know that those medications are all generics, very inexpensive, and the pharmaceutical benefit managers control most prescriptions for expensive drugs. These factors combined with the low prevalence of this disorder and well as the responsiveness to psychotherapy and supportive measure will not produce a windfall for Big Pharma.

There is an inherent bias by some against medical interventions for any disorder that seems to start out as a phenomenon seemingly explained by social or psychological factors. Grief was listed as one of the four major causal factors for depression in Interpersonal Psychotherapy (IPT) and there were no complaints.  IPT has been around for 40 years. Is that because the treatment emphasized was psychotherapy?  Throughout my career I have always had resources available for people who were grieving. Clergy are a professional resource but with the continued secularization of the country it is common to find that most people do not have an identifiable clergy person. Grief support groups are very common – both as self-help groups and groups run by professionals. The question is what if those resources are not enough to assist the grieving person? 

The third argument is that there will be “false positives” or people given the diagnosis when they are emerging from the symptoms. That supposes that the doctor has no discussion with the patient about what might be helpful including non-medical supportive measures and watchful waiting. It also supposes that the patient’s interest in what is happening with them specifically how it is affecting their life and whether they want to do anything about it is never discussed.  I don’t think most doctors – even if they are in a hurry operate that way.

The fourth argument is the danger of making a diagnosis and how that impacts the person. Grief is a universal phenomenon that everyone experiences many times in their life. Everyone knows that through experience. Empathically discussing with a person that this episode of grief is affecting them differently than others does not seem to be discounting or minimizing their emotions or experience to me. The very definition of empathy is that the patient agrees with the empathic statements as adequately explaining their experience.

A fifth argument buried in there is that clinician want to rapidly classify people so that they can get reimbursement. I have already addressed each half of that argument about but let me add – does naming a disorder mean that it did not exist before? There are thousands of examples in medicine and psychiatry of new diagnoses that basically classify earlier conditions where the diagnosis was never made before. A striking example from psychiatry is autoimmune encephalitis.  It was previously misdiagnosed as either a psychosis or bipolar disorder until the actual diagnosis was discovered. Rapid classification leads to many paths other than reimbursement. In the case of autoimmune encephalitis – life saving treatment.

The fundamental problem in writing articles about human biology from a political perspective is that it fails to address the biology. The biology I am referring to here are unique human conscious states and all of the associated back up mechanisms that make them more or less resilient, intelligent, and creative. Is the general classification “grief” likely to capture a large enough number of possibilities to qualify as a rigorous definition? We have known for some time that is not supported by the empirical evidence and that evidence has become more robust over the past 20 years. A small number of people experiencing grief will have a much more difficult time recovering and, in some case, will not recover without assistance. In spite of that, there remain biases against studies that focus on elucidating biological mechanisms or treatments.  It is easier to invoke emotional rhetoric like medicalization or psychiatrization and try to avoid the issue.  To the author’s credit none of those terms were used.

There is also the issue of what this new diagnosis suggests in terms of the science of psychopathology. Does this mean we are closer to classifying all of the possible problems of the human psyche and developing treatments? It reminds me of what one of my psychoanalyst supervisors used to say about the state of the art.  In those days there were basically biological psychiatrists and psychotherapists. He referred to anyone without a comprehensive formulation of the patient’s problem as a dial twister. Are we closer to becoming dial twisters?  I have some concerns about the checklist approach associated with the diagnosis and its understudied phenomenology. That is compounded by the limited time clinicians have to see patients these days and the predictable electronic health record templates with minimal typing of formulations.

Practical considerations aside only time will tell if the new research leads to better identification and treatment of people with clear complications of grief. That does not mean that science has all of the answers. It should be clear that the science of prolonged grief disorder like most of psychiatry only deals with the severe aspects of human experience.  There are clearly other ways to conceptualize grief and learn about it without science. The science is useful for mental health practitioners charged with providing treatments to the severely distressed and with grief the vast majority of people (90+%) will never see a practitioner and even fewer than that will ever see a psychiatrist.

 

George Dawson, MD, DFAPA

 

1:  Ellen Berry.  How Long Should It Take to Grieve? Psychiatry Has Come Up With an Answer. NY Times March 18,2022.

2:  Eisma MC, Rosner R, Comtesse H. ICD-11 Prolonged Grief Disorder Criteria: Turning Challenges Into Opportunities With Multiverse Analyses. Front Psychiatry. 2020;11:752. Published 2020 Aug 7. doi:10.3389/fpsyt.2020.00752

Excerpted per open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).

3:  Prigerson HG, Horowitz MJ, Jacobs SC, Parkes CM, Aslan M, et al. (2013) Correction: Prolonged Grief Disorder: Psychometric Validation of Criteria Proposed for DSM-V and ICD-11. PLOS Medicine 10(12): 10.1371/annotation/a1d91e0d-981f-4674-926c-0fbd2463b5ea.

4:  Lenferink LIM, Eisma MC, Smid GE, de Keijser J, Boelen PA. Valid measurement of DSM-5 persistent complex bereavement disorder and DSM-5-TR and ICD-11 prolonged grief disorder: The Traumatic Grief Inventory-Self Report Plus (TGI-SR+). Compr Psychiatry. 2022 Jan;112:152281. doi: 10.1016/j.comppsych.2021.152281. Epub 2021 Oct 21. PMID: 34700189.

5:  Shear MK, Reynolds CF, Simon NM, Zisook S. Prolonged grief disorder in adults: Epidemiology, clinical features, assessment, and diagnosis. In Peter P Roy-Byrne and D Solomon (eds) UpToDate https://www.uptodate.com/contents/prolonged-grief-disorder-in-adults-epidemiology-clinical-features-assessment-and-diagnosis#H210445955 accessed on 03/21/2022

6:  Klerman GL, Weissman MM, Rounsaville BJ, Chevron ES.  Interpersonal Therapy of Depression.  Basic Books, New York, 1984.

7:  Ratcliffe M. Towards a phenomenology of grief: Insights from Merleau-Ponty.  European Journal of Philosophy 2019; 28: 657-669  DOI: 10.1111/ejop.12513

8:  Clayton PJ. Bereavement in Handbook of Affective of Disorders.  Eugene S. Paykel (ed). The Guilford Press. New York. 1982  pages 413-414


Supplementary 1:

Quote from an initial post on this subject 9 years ago as written by Paula Clayton, MD:

"There are many publications that deal with treating psychiatric patients who report recent and remote bereavement. It is possible to find a real or imagined loss in every patient's past. However, for the most part, because there is little evidence from reviewing normal bereavement that there is a strong correlation between bereavement and first entry into psychiatric care, those bereaved who are seen by psychiatrists should be treated for their primary symptoms. This is not to say that the death should not be discussed, but because these people represent a very small subset of all recently bereaved, they should be treated like other patients with similar symptoms but no precipitating cause. A physician seeing a recently bereaved with newly discovered hypertension might delay treatment one or two visits to confirm its continued existence, but treat it if it persists. So the psychiatrist should treat the patient with affective symptoms with somatic therapy but only if the symptoms are major and persist unduly. A careful history of past and present drug and alcohol intake is indicated. Then, the safest and most appropriate drugs to use are the antidepressants. Electroconvulsive therapy is indicated in the suicidal depressed." (Paykel p413-414)

Sunday, March 13, 2022

Class Warfare....





Americans operate on the illusion of a classless society. It is generally an implicit understanding that I did not have much of a handle on until I worked with teachers from the United Kingdom in my early to mid-20s.  Those teachers were always talking about the “working class” and those struggles and how it translated to national politics. They had well developed positions on international politics on the same basis. 

For the record, my family of origin was solid working class or the American equivalent “blue collar”.  During my father’s short lifetime, he was a railroad fireman and then engineer.  I can recall watching him shovel coal into a steam engine when I was about 5 years old.  One grandfather was an ore puncher or a guy who attends to an emptying iron ore rail cars - until he died from an apparent head injury.  My other grandfather ran a dray business hauling goods for other people and moving families from house to house. In late high school I assisted my grandfather moving and hauling things around ranging from flower boxes to grave sites to carrying very large pianos up several flights of stairs.

When you are raised in that environment it is easy to develop a distrust of authority – because let’s face it – in a capitalistic society altruism is at a minimum. People at all levels are trying to exploit you for their own gain. In the case of my father, he was in a system that could potentially pay you well when you were in your mid-50s or 60s.  If you were younger than that a seniority system kept you from working full time or enjoying the more premium jobs that did not require extensive travel or hardship. You could get “bumped” from a job at any time by an engineer with more seniority.  You could also be called up out of the blue to take a job that nobody else wanted.  On the days that my father did not want to work the call up jobs we were all given the code words: “Your father is not here today.”  That meant if I picked up our wall phone and my father was sitting at the kitchen table a few feet away and I heard a dispatcher say: “Is George there?” I knew it was my family duty to say: “No he’s not here.”

And who could blame him? I knew one of those jobs was an all-day run for about 220 miles (switching cars along the way). During the one-night layover – he slept on a wooden bench in the locker room at a train station and then came back the next day. I was a visitor to many of those locker rooms as a kid and knew what they all looked like - stark, dingy, sweaty furniture, and smelling like diesel fuel and Lucky Strikes. I also knew he did this to save money because we were usually strapped for cash.

But my father’s role was to educate me about the basics of growing up in a blue-collar family as well as live the practical aspects. I remember him showing me his union paper.   There on the cover was a picture of the home of the President of the Union. I guess they were unconcerned about optics in those days. It was a large home sitting on the high bank of a river.  I probably inherited my dead pan affect from my father but on this day, he was particularly animated.  I usually only noticed that if he was watching opera or comedy on TV.

“Do you see this house, George?! Do you think the guy who lives in this house cares about what happens to us?!”  It didn’t matter if that guy was once an engineer. He had migrated to the managerial class and that defined the relationship.

Even back then I knew it was a rhetorical question. I had been schooled in the fact that there was a mandatory withdrawal from his paycheck for union dues and that he could not work unless he was a member of the union. There was even an occasion where his union went on strike against the railroad he worked for and after getting appropriate clearances – he went to work for a competing railroad until the strike was over.  It wasn’t like he had a choice anyway. We lived on a paycheck-to-paycheck basis.

The blue-collar ethos was about more than suspicion of the managing class. There was an identification with coworkers and at times joint projects rather than socialization for socialization’s sake. My father decided to replace a rotted footer in the porch just off our kitchen one day.  By noon there were a dozen railroad coworkers there figuring out how to do it for the least amount of money. They finally located a significantly distorted 4” x 12” x 16' plank and used a car jack to bend it into place until it was nailed securely.  That was the first and last time I saw many of those men.  A fellow engineer who was a good friend of my father came over one day and they built an entire set of kitchen cabinets from scratch.  I never saw my father do any carpentry after that. The focus was on doing what needed to be done for the least amount of money.  

During that team effort on our porch on of the common topics of conversation was the work values of some of their colleagues. There was unanimous agreement about a car knocker who everyone seemed to know.  Car knockers on the railroad maintained all of the cars. That job breaks down to many skills and a fairly broad knowledge base. Everyone there commented about how this particular car knocker would always complete everything he knew how to do before passing the job along to someone else. That work practice was very highly regarded.

The social life of my parents consisted of brief daytime visits with two coworker friends from the railroad and a friend who my father used to play baseball with in his early 20s. My parents went out on New Year’s Eve to a local dinner club and that was it. No weekly weekend celebrations that are common today. But even more significantly – no rubbing elbows with the managerial class in hope of advancement. One of the significant blue-collar features is that people only socialize with whom they want to.  Socialization is not seen as a way to advance your career or develop relationships in the workplace apart from your overall competence. Another illusion of the blue-collar existence is the idea that you will be judged on your work quality and nothing else.  At least until you notice people with fewer work skills being advanced due to nepotism and fraternizing with the boss after work.  

 Another feature of the blue-collar existence was adherence to certain rules about money and specific social relationships.  Illegal activity was to be avoided at all cost. If you don’t have the money, you don’t do the activity. I can recall being lectured by my father for watching a baseball game from outside a ballpark after the fences had been torn down. His emphasis – if you can’t buy the ticket don’t go. Teachers were highly respected but the role of education was uncertain. Good grades were expected but there was minimal help at home and no clear career advice.  Some of the educated were after all members of the white collar and managerial classes. There was an explicit message that if you had a problem with a teacher you would run into an even bigger problem at home.  Teachers were unequivocally understood to be right and you were wrong.

A contrasting feature compared with the current pandemic is that I was born during a polio pandemic. Some kids in the neighborhood were acutely ill and one of them who lived a few blocks away was permanently paralyzed.  We all got the required vaccinations to attend public school and both the Salk and Sabin vaccines for polio. We also got smallpox vaccinations. There were no antivaccination protestors in those days.  Even though medicine was clearly more primitive 50 years ago - blue collar families were all for it. 

The politics was more clearcut even though most politicians on both sides of the aisle were moderates. Both of my parents were Democrats.  My maternal grandmother was a Democrat because “they are for the little guy.”  My maternal grandfather was a Republican because they always talked about cutting taxes but he also would get a faraway look in his eye and say: “George – someday there is going to be a revolution. All politicians are crooked!”  My grandmother encouraged a sensible and moderate life style. She lectured me on “roadhouses” when she learned I had gone to a local college bar.  The Eisenhower administration was ending to be followed in fairly quick succession by JFK and LBJ. America’s streets were not flooded with guns like they are now. Gun violence was not like it is now.  The NRA taught hunter safety courses and most blue-collar kids took the course in order to go hunting or target shooting. There were no school shootings but kids died in hunting accidents and by suicide. There was some building concern about the domino theory of communism in southeast Asia and the threat of nuclear war with the USSR.  The idea that nuclear was survivable was alive and well and there were several bomb shelters designated across the town.  I was charged with dismantling one of them as part of my work-study job in college about a decade later.

The transition to white collar work from a blue-collar family is interesting and complicated by the generations of white-collar people who you encounter. That transition was noticeable at the level of medical school. There it became apparent that there were a number of second and third generation physicians and many did not relate to people the same way that the blue-collar class did.  But the most striking transition occurred in the workplace when you are face-to-face with the same kinds of administrators that my father encountered in his railroad job.  People who have the power to fire you or severely reduce your income or professional prestige and don’t hesitate to do it on a whim. People who can actually do whatever they need to do to discredit you. In the last 40 or 50 years there has been a proliferation of this managerial class and the benefits have been uncertain at best. I have advanced the argument many times that the new managerial class has added no value at all. But then again based on what I have written so far – you knew that I would.

Today we are faced with a severely fractured society. Vast areas of rural American support policies that seem like a return to the 1960s blue collar world in terms of turning back women’s rights, pretending that there has been significant progress on racial equity, maintaining law and order by not questioning the police, and making sure that tax dollars are not given away to people seen as working less hard than they do. In what is the ultimate irony these same people have come to believe that a probusiness party lax on regulation is the best way to preserve their way of life.  They are turning to the same people who they have been skeptical of for decades to make these changes. This pivot has not been without cost.  Many blue-collar families have fragmented over these obvious contradictions as well as problems with the frontman of the party.  If you have blue collar values – the only way you can ignore thousands of lies is to ignore that they are lies in the first place. The only way you can ignore the gun violence in schools and on the streets is to blindly restate that this has something to do with the Second Amendment and all of the political biases that goes along with that, while ignoring the fact that it is a desperate political attempt to stay relevant.

But there is a deep inconsistency in that decision making – not just because of the sudden blind trust of the epitome of the white-collar world. It is a white-collar world that is clearly affiliated with interests inimical to most of the American people both culturally and in terms of foreign security. 

 

George Dawson, MD, DFAPA


Graphics Credit:

Benjamin Morawek, CC BY-SA 2.0 <https://creativecommons.org/licenses/by-sa/2.0>, via Wikimedia Commons

Sunday, February 27, 2022

Scientific realism versus instrumentalism

 


“A philosopher who is not trained in a scientific discipline and who fails to keep his scientific interests alive will inevitably bungle and stumble and mistake uncritical rough drafts for definitive knowledge.  Unless an idea is submitted to the coldly dispassionate test of scientific inquiry, it is rapidly consumed in the fire of emotions and passions, or else it withers into a dry and narrow fanaticism” 

Karl Jaspers

Way to Wisdom, p. 159

 

I encountered 2 philosophical ideas today that I did not have any disagreement with and decided I would take that as a sign and discuss them here on my blog. Readers may have noticed that I am very skeptical about what philosophy adds to psychiatry and have posted numerous examples over the years. Today the above quote was posted on Twitter and it is an idea that I completely agree with. One of the problems that I have with philosophy in psychiatry is that is generally written as a rhetorical attack on the field. That is easy to do when you control the premise and that premise is generally false. There are numerous examples but the most obvious one is defining what you consider a disease to be and then concluding that no mental illnesses are diseases. More specific examples are available such as using similar definitions for addiction and then concluding that addiction is not a disease. Many of the people posting these arguments are not scientists or clinicians but in some cases are clinicians who have yet to have ever seen the patient they are talking about or who have never seen a patient – period.  To a large extent I think this is what Jaspers is focused on in this quote. It comes from a chapter in the reference book that is labeled as “Appendix 1: Philosophy and Science” and states that it was reprinted by permission from the Partisan Review.

The second opinion piece was from Kenneth Kendler, MD a leading expert in psychiatry, genetics and psychiatric research. He also has written extensively on the evolution of psychiatric thought over the decades and how philosophy applies to psychiatry. I have probably read at least a hundred papers written by Dr. Kendler in the past 30 years – and that is a small number of the papers he has written. I have also read his book Why Does Psychiatry Need Philosophy wherein he and his co-authors are focused on issues of phenomenology, nosology, and the degree of explanation as the subtitle suggests.

In the opinion piece (3), he takes a brief look at the philosophy of science and how that applies to the DSM.  He describes the main philosophical divisions as scientific realism and instrumentalism as they apply to diagnoses.  With scientific realism whatever the diagnostic construct - it is accepted at face value.  They are thought to really exist that way. The best examples I can think of from the DSM are Dissociative Identity Disorder and Intermittent Explosive Disorder.  Both are highly problematic and yet – there they are in the DSM. Further - the people who believe they exist seem undeterred in their use and they seem to be just carried along with subsequent revisions of the DSM.  Instrumentalism on the other hand sees diagnostic constructs as a work in progress.  They are not accepted as ultimate diagnoses but are subject to the scientific process of validation by empirical evidence. A good example in that case would be schizophrenia subtypes.  Previous editions of the DSM had 5 subtypes of schizophrenia including paranoid, catatonic, disorganized, residual, and undifferentiated.  Psychiatrists treating acute schizophrenia noticed that the subtypes were not consistent over time and the same person could be diagnosed with different subtypes. On that basis, the DSM-5 revision dropped the subtype classification but unfortunately implemented a schizophrenia spectrum of disorders.  I think that applying a physical concept to heterogeneous group of biologically determined disorders is probably a step in the wrong direction and that an instrumentalist approach will eliminate spectrums in the future along with Dissociative Identity Disorder and Intermittent Explosive Disorder

Kendler goes on the discuss 5 arguments in favor of an instrumentalist approach.  Before I raise those points, why would everyone not be in favor of this approach? Certainly, math and science majors would. Even though you can specialize in physical and biological science before medical school and students at that level don’t get much explicit instruction in the history of science – it happens nonetheless. Most high school students in the US are exposed to Darwin, Lamarck, and the DNA double helix as sophomores in high school. Almost all of the main concepts in physics and chemistry include some discussion of innovation and how earlier theories were rejected. That approach is more notable in medical school where some of the timelines and necessary technology become clearer. All of that information greatly favors an instrumentalism over scientific realism.  Although psychiatry is a relatively new discipline, it is clear that diagnostic systems have been greatly modified over the past 100 years from the Unitary Psychosis model o the 19th century.

His first argument - pessimistic induction highlights the history of changes in diagnoses in the past and suggests that we should expect the same pattern in the future. A counterargument is that significant refinement has occurred and we can expect fewer errors than in the past but at any rate these observations need to be made.  The second argument is that given the nature of descriptive diagnoses rather than direct test observation determining validity will always require an instrumentalist approach.  The third argument is that the uncertainty about two competing diagnoses can be empirical or conceptual. Kendler favors the latter and that means changing the construct. The fourth argument is that scientific advances in psychiatry cannot be predicted or anticipated and are potentially transformative.  An empirical approach is required to test the future approaches against the current approaches and make the indicated modifications.  The fifth argument reduces a reverence bias toward existing diagnoses, much like clinicians use the provisional diagnosis term to reflect diagnostic uncertainty. 

He touched on the problem of how polygenic heterogeneous disorders can lead to the philosophical problem of multiple realizability.  That is - multiple genotypes leading to the same phenotype and the implications that has for moving to a diagnostic system that includes etiology. He points out that psychiatric disorders have higher degrees of polygenicity.  He briefly alludes to the potential problem of scientists with epistemic privilege studying nosology and phenomenology – but concludes on a more positive note about current research methods not available to previous generations.

Al things considered this did not seem like a powerful argument for philosophy in psychiatry. The current arguments in favor of instrumentalism seem like the general process of science.  The exceptions mentioned for psychiatry did not seem that specific relative to other specialties diagnosing complex polygenic disorders. I really wonder who the psychiatrists are who accept DSM diagnoses at face value?  I don’t think that I have ever met one.

That leads to the question of whether there are philosophical approaches that might be useful to psychiatry.  In my research for this post – I did find a fairly interesting one called constructive empiricism by von Fraassen (7,8).  Simply defined constructive empiricism states:  “Science aims to give us theories which are empirically adequate; and acceptance of a theory involves as belief only that it is empirically adequate.”  This is a departure from scientific realism and the premise that science is giving us the truth and belief in the theory means believing it is true. There is debate regarding the empirical adequacy of a theory with the critics using circularity arguments and the defenders pointing out that it is determined by scientists for specific goals. Philosophical debates tend to be endless and there are seldom any clear answers.  To me constructive empiricism seems to be an accurate description of what happens in psychiatry both at the biological and phenomenological levels. It certainly applies to the diagnoses of schizophrenia spectrum as opposed to subtypes and Dissociative Identity Disorder used in the original paper and many other papers written by Kendler on the evolution of various diagnoses over time. 

The critics of psychiatry are another story. There are people in the world right now who attack the entire diagnostic system of psychiatry. They either don’t have alternatives or the suggested alternatives have not been widely validated or adopted. In some cases, the theoretical basis for their proposed system is highly questionable. These same critics always seen to caricature the diagnostic process as one that is based on neither scientific realism or instrumentalism. The best example I can think of is any paper written that characterizes the DSM as the Bible of psychiatry.  That speaks not only to a general level of ignorance about how it is regarded in the field but also the philosophical bias suggesting the approach to the DSM has been static and not based in reality - even though major disorders have been present for centuries.  The critics also have an associated lack of knowledge about the biological constraints – even as they are briefly outlined in this opinion piece.

These critics whether they are antipsychiatrists or not seem to believe that what is in the DSM is accepted as the truth based on blind belief by psychiatrists and there is no evidence that is true now or at any point in time.  The observable changing diagnostic criteria over time and teaching future generations about all of the constraints is the best way to address empirical adequacy.

         

George Dawson, MD, DFAPA

 

References:

1:  Jaspers K.  Way To Wisdom. Yale University Press, New Haven, 1951: p. 151.

2:  Kendler KS.  Why does psychiatry need philosophy? In: Kendler KS, Parnas J, eds.  Philosophical Issues In Psychiatry: Explanation, Phenomenology, Nosology. Baltimore, MD; The Johns Hopkins University Press, 2008: 1-16.

3:  Kendler KS. Potential Lessons for DSM From Contemporary Philosophy of Science. JAMA Psychiatry. 2022 Feb 1;79(2):99-100. doi: 10.1001/jamapsychiatry.2021.3559. PMID: 34878514.

4:  Chakravartty, Anjan, "Scientific Realism", The Stanford Encyclopedia of Philosophy (Summer 2017 Edition), Edward N. Zalta (ed.), https://plato.stanford.edu/archives/sum2017/entries/scientific-realism

5:  Eronen MI. Psychopathology and Truth: A Defense of Realism. J Med Philos. 2019 Jul 29;44(4):507-520. doi: 10.1093/jmp/jhz009. PMID: 31356663.

6:  Kendler KS. Toward a limited realism for psychiatric nosology based on the coherence theory of truth. Psychol Med. 2015 Apr;45(6):1115-8. doi: 10.1017/S0033291714002177. Epub 2014 Sep 2. PMID: 25181016.

7:  Monton, Bradley and Chad Mohler, Constructive Empiricism. The Stanford Encyclopedia of Philosophy (Summer 2021 Edition), Edward N. Zalta (ed.), https://plato.stanford.edu/archives/sum2021/entries/constructive-empiricism.

8:  von Fraassen, Bas. Constructive Empiricism Now. Philosophical Studies, 2001; 106: 151–170https://www.princeton.edu/~fraassen/abstract/docs-publd/CE_Now.pdf

Concept Credit:  Dr. Ahmed Samei Huda a colleague from the UK came up with the concept that the critics of psychiatry are functioning at the level of scientific realism when psychiatrists are not.  That occurred during a Twitter discussion. 


Supplementary 1:  In the philosophy world there are much more detailed and varying definitions of scientific realism (4) than what Kendler discusses in the opinion piece.  The most accessible article I could find on the subject is by Eronen (5) that is more or less a refutation of Kendler and Zachar’s position on scientific realism. I say more or less because the author takes various positions to illustrate that scientific realism is necessary or at the minimum his Kendler and Zachar’s position on scientific realism may be closer to his that not. What I like about the Eronen paper is that he uses very clear examples with clear diagnoses like anorexia nervosa to make his point. My longstanding arguments about the validity of major psychiatric diagnoses is that they have always been there and more than anything that has driven the need for psychiatry and psychiatric care.


Graphics Credit:

Karl Jaspers downloaded from WikiMedia Commons on 2/27/2022 per the following:

Universitätsbibliothek Heidelberg, CC BY-SA 4.0 <https://creativecommons.org/licenses/by-sa/4.0>, via Wikimedia Commons  at the following URL: https://commons.wikimedia.org/wiki/File:Karl_Jaspers_(HeidICON_33479).jpg


Friday, February 18, 2022

Coercion versus something else?

 


My motivation for writing this post comes from recent activity on Twitter about “coercive care” in psychiatry and an opinion posted there by a psychiatrist suggesting that psychiatrists need to be aware of their role as an agent of the state when they are engaged in involuntary treatment. After seeing this I checked the literature and there were papers published on the subject – so I thought I would write a post about the issue – specifically whether coercion is an appropriate word to use and how it compares to involuntary treatment as a description and a concept.

I don’t consider the issue lightly.  For most of my career I have been in acute care settings that required knowledge and skill in negotiating involuntary care scenarios – specifically emergency holds, probate court holds, civil commitments, conservatorships, and guardianships. That involved hundreds of court appearances in 7 counties and 2 different states.  I also testified as an expert on the issue of prolonged state hospital stays for a patient advocacy organization and testified in both malpractice cases and a criminal responsibility case.  I have personally seen how local politics can affect the civil commitment and conservatorship laws to the point that they are actively ignored for various reasons. In that unstable landscape, the staff responsible for treating the patient needs to be very flexible and innovative to provide the necessary care.  The following graphics show what that care generally looks like.  It is a diagram of how involuntary treatment gets initiated and carried out.

The commonest path is that there is an incident in the community, emergency medical services are activated, and the patient is placed on a hold and transported to the emergency department (ED).  While there an ED physician and mental health clinician (typically a social worker) makes and assessment of the patient and determines if they can be discharged, admitted on a voluntary basis, or admitted on an emergency hold. 

Following the admission, the inpatient staff makes their respective assessments and typically discuss their findings and the plan in team meetings. If the patient was admitted on a timed hold (72 or 96 hours) and a determination is made that the patient cannot be treated on a voluntary basis prepetition screeners are contacted.  They come in and see the patient and collect more collateral information than the inpatient team has access to.  They compile this in a prepetition screening document and in a team meeting separate from the hospital staff (they are typically county employees) make a determination that the hold will be cancelled or they will refer the patient for further court intervention.  If they determine to not support the emergency hold, the patient is typically discharged and it is illegal for a physician to immediately place them on another emergency hold. If they are referred to the court a probable cause hearing is held.  At that point the judge can release the patient or refer for a final hearing.  Before any final hearing, 2 court appointed examiners (typically a psychiatrists or psychologists employed by the county) will see and assess the patient. They will testify in court and give specific treatment recommendations to the court – independent of the hospital staff charged with treating the patient. At the final hearing the patient can again be released with no court intervention based on a judge’s decision. They can also be court ordered to follow treatment recommendations including further hospitalization and medications.  Courts can also accept a stay of commitment – meaning that the patient is not formally ordered to accept treatment for a duration of time but they can accept treatment and follow up and if everything is going well at 6 months any involvement with the court self dismisses.  There is a similar intervention for persons who have been formally committed called a provisional discharge. In that case, the person is discharged with a plan to report back on outpatient progress. The structure of this process highlights the fact that no single person or discipline makes a decision about involuntary treatment. In addition, the statutory requirements for mental illness or substance abuse do not specify any particular diagnosis but depend on whether there is behavior that is self-endangering, harmful to others, or significantly affects the person’s ability to function in their own interest at the most basic level (adequate self-care in terms of food, housing, and addressing significant medical problems).

The question critical to this post is how is this process coercive rather than involuntary?  And is there a difference between those terms?   Just looking at standard definitions coercion is clearly more insidious and it implies malignant intent. The Webster’s definition is “to compel by force or intimidation; to bring about by force; to dominate or control esp. by exploiting fear, anxiety, etc.”  Using the same source, the definition of involuntary is “not voluntary, independent of one’s will.”  At this level, coercion is nothing medical staff are ever trained to do and in fact would constitute a violation of professional ethics.  In psychiatry, the training is focused on helping psychiatrists overcome standard biases that people experience when interacting with others who have clear problems with severe psychiatric disorders.  The entire focus of psychiatric training is developing a cooperative and helpful relationship.

What about legal definitions and statutes pertaining to coercion?  The legal definition of coercion is essentially the same as the dictionary definition:  Verbal and/or physical threats and other forms of intimidation in order to force someone to do something/not do something that they are otherwise legally allowed/not allowed to do.  Laws against coercion in federal statues range from the obvious forms like sex trafficking to threats of retaliation for political activity or exercising rights at work. In all of these cases, the victims of coercion are generally going to be capable of making decisions in their best interest but are unable to make willful decisions due to coercion.

It turns out that an entirely different level of analysis has been applied to the issue of coercion and psychiatric patients. That level of analysis is done by philosophers using thoughts about coercion from previous works on ethics.  For example, Schramme (2) expands arguments from Frankfurt’s work to discuss specific examples of coercion. He begins with the informed consent model.  I consider Gutheil and Appelbaum to be authoritative in this area and they discuss three elements of informed consent: information, voluntariness, and competence (3).  The adequate information is discussed from the perspective of a professional level of disclosure and also a “reasonable person” or the level of information that most people would expect. The expected information varies from state-to-state and in some cases for psychiatry there is a written information standard. For example, in the State of Minnesota, antipsychotic medication consent requires a signed consent form about those potential side effects.  Voluntariness means consent is freely given. It is often assumed that since psychiatric patients are generally considered to be vulnerable adults who may be dependent on institutions that this is a form of situational coercion. Gutheil and Appelbaum point out that this would in effect not recognize the decisions made by large numbers of people in institutions just because of the place they reside. They describe more clearcut and explicit forms of coercion such as threatening the loss of food or clothing if the patient does not follow recommended treatment. Competence means that the patient has mental capacity to understand the information presented and may a make a reasonable decision in order to give informed consent.  Psychiatric disorders can affect all three elements of informed consent.

The philosophical look at coercion is a bit more complex and it is selectively applied to the case of psychiatric care. Just looking at the demographics raises some questions.  There are 1.3 million people in the US under guardianship or conservatorship. At the same time there are 6.96 million people with dementia, 500,000 people with moderate to severe intellectual impairment, 36.25 million with subjective cognitive impairment, and an undetermined number of people with cognitive impairment and impaired capacity secondary to severe psychiatric disorders. Those numbers suggest that there are not nearly enough guardianships in place to provide substituted consent for people during medical emergencies.  In many jurisdictions guardianships and conservatorships have to be pursued by family and that often creates an undue financial burden. In the jurisdictions that actively ignore conservatorships and guardianships – persons needing them often incur unnecessary medical risk because treating physicians realize that they cannot accept their consent to procedures involving risk – like surgeries.

Schramme has analyzed the issue of coercion in the following ways. He breaks coercion down to threats and offers.  For the purpose of his discussion, he states that he is exclusively focused on autonomous choices that are contrary to the will of the patient.  These choices cannot be made under the influence of threats but he outlines 3 scenarios where informed consent is lacking:

1.  A patient is not able to give informed consent – I think he makes a critical mistake here by stating that most psychiatric patients are able to give consent and their capacity is not globally impaired.  It clearly depends on illness severity and the stage of treatment. Most forensic hospitals are charged with the task of restoring competency to mentally ill offenders so that they can proceed to trial.

2.  A patient disagrees with treatment and makes that known but he is forced to accept treatment anyway. The example given is a patient who if forced to take medication because he is potentially dangerous to others. Schramme depicts this as “a conflict between the patient’s will and the opinion of the doctor”.  But where does the dangerousness come in? Why is the patient unable to see that he is at risk from an extremely adverse outcome (aggression and long-term incarceration or injury and possible death due to a confrontation with the police) and not incorporate that into his refusal?

3. A patient passively complies with a treatment recommendation and does not make an overt decision. Schramme states that although this would not typically be considered as coercive treatment – it all depends on whether the consent is given freely or not. The implication is that passive consent is not necessarily informed consent.  Schramme invents the term “interactive coercion” to suggest that psychiatric patients can be coerced by the interpersonal relationship beyond what is typical of medical paternalism. That presupposes that either nonpsychiatric physicians do not have relationships with their patients, psychiatrists are masters at manipulating people, or some combination.

From that point he goes on to provide 3 examples of interactive coercion  

Case 1:  The psychiatrist predicts that “damage or harm” will occur if the patient does not follow certain course of action. This may or may not be coercion. Schramme gives the example of taking away the patient’s cigarettes or writing them a suboptimal report (the damage or harm) unless they comply with the prescribed course of action.  He acknowledges that harm can be predicted due to non-compliance and it may not be a threat but a natural consequence of untreated illness. Prediction of future causal events is a warning and not a threat hence no coercion (p. 360).  On the other hand, he suggests an “unusual” prediction such as electroconvulsive therapy (ECT) if the patient had no previous experience either it would constitute a threat.  The two necessary features for predicted harm to be a threat/coercion would be that it needs to be intentional and unusual.

Case 2: The psychiatrist proposes a “detrimental unusual consequence if the patient does not comply an example of effective threats as coercion. In this case, if the threats are ineffective, they are inconsequential, lead to no coerced decision. Schramme points out that “there is no rigid line between a threat and a warning”. He gives an example of a patient interpreting an action as a threat that may have had more to do with the social roles of patients and nurses on the ward.

Case 3: The psychiatrist offers a beneficial unusual consequence if the patient complies with a specific task. In this case there may be intermediate conditionals. For example, the patient may not be motivated or feel like socializing but forces themselves to do it anyway to get the offer.

Schramme introduces the idea of irresistible threats and offers at this point. An offer becomes irresistible when there is no other real alternative.  In this case even if the choice is voluntary, it can still be against one’s will.  The best example is substance use disorders where the person may not want to take the drug but acts on the drug as an irresistible offer rather than a preferred motivation to remain abstinent. This is an example of an offer that is irresistible and therefore coercive in that it they are against the will of the person.  This is not a hard rule and Schramme emphasizes that all offers are not bad and they depend on the subjective preferences of the patient.  He goes on to develop the idea that “manipulation and coercion – at least in psychiatric hospitals – do not only stem from predicted consequences which bring people to do A, namely that they to prevent bad things from happening.” (p. 367). Instead, he defines it as “an influence on the autonomous will of the patient and not on the welfare of a person”.  He closes by pointing out that institutional and interpersonal dependencies can also result in irresistible offers to psychiatric patients.  He cites some examples that today are irrelevant or exaggerated. For example – giving a patient cigarettes if they take a medication or the offer of a “good report” for group attendance.  I have not observed either of these happening on inpatient units over the course of my career even when smoking was allowed on inpatient units.  Even so, Schramme concludes that these coercive offers are not necessarily morally wrong because “it might be good to sacrifice the freedom of the patient for the sake of his well-being.” (p. 368).  That is more than a trivial distinction and I would argue is the basis of both civil commitment and guardianship or conservatorship.

Szmukler and Appelbaum (4) reviewed the coercion literature to date and described their own approach to the issue of coercion. Their first step was noting that coercion was a loaded term and describing a graduated systems of treatment pressures including:

(1) persuasion

(2) interpersonal leverage

(3) inducements

(4) threats

(5) compulsory treatment (in the community or as an inpatient).

They provide an example of a community psychiatric nurse following a patient in the community and how each of these pressures may work. They develop models based on paternalism and capacity/best interests.  Their definition of paternalism based on previous research is given as:

“…a person is acting paternalistically towards another if his action benefits the other; his action involves violating a moral rule with regard to the other; his action does not have the other's past, present, or immediately forthcoming consent, and the person believes he or she can make his or her own decision on the matter. A paternalistic act requires justification because it involves the violation of a moral rule but with the intention of preventing a harm to the person.” (p. 240)

A series of questions is provided to answer whether or not a paternalistic intervention is indicted.  Answering those questions for a typical emergency admission to an inpatient setting is typically balancing the deprivation of personal liberty against death and disability.  More subtle tradeoffs don’t end up as admissions to inpatient units.

A capacity/best interest analysis is just the way it sounds.  The patient has impaired decision making and is not able to make decisions in their best interest. Best interest has a degree of subjectivity but the authors describe some general guidelines based on previous work. The authors suggest that clinicians need a consistent ethical framework for approaching these problems that is as rigorous as the typical technical frameworks they use in practice.  

“Protection of others” is described as a more difficult problem for Szmukler and Appelbaum largely because of the subjectivity involved. They discuss for example the low percentages of patients with mental illness who are aggressive and the impossibility of prediction. They do not mention that a number of features (acute care settings, acute threats, history of violence/aggression, psychosis, pooling of cases, access to weapons) may greatly increase risk but they are writing from the perspective of community rather than inpatient care. They make an interesting comment: “Mental health professionals may accept an obligation to notify appropriate authorities if there is a serious risk of harm to others, but what is serious and who should instigate or implement coercive responses is a matter for debate.”  (p. 242). My understanding is that there is a duty to warn in every state and the clinician not only needs to make a good faith effort to contact the potential victim and take what other steps may be necessary (eg. calling the police) to protect that person.

With that review, what assures that the term coercion is not just another term used to inappropriately criticize monolithic psychiatry?  The standard dictionary definitions implying malignant intent is certainly consistent with inappropriate criticism.  Schramme acknowledges that there are situations where informed consent cannot occur due to a lack of capacity but goes on to elaborate on treatment refusal where there is probably lack of capacity and consent where the patient interactively coerced by institutional or interpersonal scenarios.  There is a high degree of subjectivity involved in the interactive coercion scenarios.  Schramme seems to approach the problem hypothetically rather than interactively. For example, as a clinical psychiatrist why would I ask if the patient was perceiving a warning or a threat – I would just ask them. In many cases agitated and paranoid patients are spontaneously accusing staff of threats and malignant intent before any assessment or conversation has occurred.

The best way I can think of how to proceed is to post a vignette – in the standard way that they are posted these days – a composite of features noted over the course of 25 years and not any specific patient:

 

Case Vignette

 28-year-old man with schizophrenia and Diabetes Mellitus Type 1 since age 8. He stopped treatment for schizophrenia a year ago. Since then, he has been hospitalized for recurrent diabetic ketoacidosis (DKA) four times and the consult-liaison (C-L) team has noticed progressive cognitive problems. He is discovered by the police in a park at night. The air temp is -5°F/-20°C and he was not wearing adequate clothing (no jacket, caps or gloves). In the ED he is noted to have a frostbite injury of his feet and hands. He requests immediate discharge and states that he will follow up with medical and surgical care on an outpatient basis. He refuses to consider psychiatric care. He denies any hallucinations or delusions.  He is admitted to the burn unit on a 72 hour hold by the ED physician.  Is this coercion?

He is seen the next day by the C-L team. He has some mild cognitive impairment and memory problems.  He is detached and not saying much about why he was hospitalized. His affect is restricted but he does not appear to be depressed. He is requesting discharge but has no clear plan of what he will do when he leaves.  When asked about the diabetes mellitus diagnosis he replies: “I can’t have it because I don’t have a pancreas.”  The C-L team recommends referral to inpatient psychiatry and proceeding with a probate court referral.  The team speaks to a family member there who talks at length about the family’s concern for the patient’s safety and their relief that he is hospitalized. Is this coercion?

This is a realistic description of how patients are admitted to acute care hospitals. The police officers in this case call EMS and the patient is assessed by paramedics. The patient is taken to a local emergency department where he is seen by a physician and a social worker and admitted. In this case an involuntary hold is initiated by the police or by the ED physician. A psychiatric diagnosis per se is not required since the statutory definitions of mental illness are based on impaired judgement that endanger the person or their health.  Independently 6 people (none of whom were psychiatrists) agreed those conditions existed.

He is seen and treated by surgery staff. He passively goes along with treatment but there are obvious concerns about his capacity. Is this a case of “interactive coercion” by surgical staff per Schramme’s formulation? He is non-disclosing with psychiatry staff but the key observation is that he no longer believes he has diabetes because he no longer has a pancreas.  This is not a basis for adequate medical decision making or self-care and that is further documented by his 4 episodes of diabetic ketoacidosis, continued inability to manage this condition and the question of cognitive impairment after episodes of coma. This patient is referred for civil commitment and will be seen by pre-petition screeners (typically one screener but a team of 4-5 people make the decision), a defense attorney, 2 court appointed examiners, and a probate court judge.  A total of about 9 people are involved in a process to determine if the patient meets statutory requirements for civil commitment and whether treatment should be court ordered.

Looking at the formulations of both Schramme and Szmukler and Appelbaum is instructive.  The probate court proceeding that I describe is clearly a safeguarded capacity/best interest scenario. The patient clearly lacks the capacity to make an informed decision and consent on the basis that he no longer recognizes that he has diabetes or that it needs to be treated despite life threatening consequences. It is very clear that he would not get adequate treatment of diabetes or the frostbite injuries if he was not hospitalized, observed, and actively treated. By their formulation they would say that maximum treatment pressure is exerted by compulsory treatment. In the final analysis, the ethical issue is that the patient is being deprived of his right to continue to wander the streets without adequate clothing or medical treatment for the compulsory treatment.  Apart from a magical immediate restoration of capacity is there a better short-term solution that is better designed to protect his rights? I don’t see any.

An additional consideration is the issue of agency on the part of the inpatient psychiatrist.  That psychiatrist has a fiduciary responsibility to the patient. That involves discussing all relevant aspects of diagnosis and treatment with the patient, including the concerns about his ability to care for himself. Is that psychiatrist and agent of the state or as some philosophers like to put it – the will of the state is being enacted though that psychiatrist? Definitely not and here is why – the will of the state is transacted through the commitment court and all of those personnel.  The treating psychiatrist is unnecessary for the commitment proceeding and the court is focused on what their examiners conclude.  Psychiatrists have no personal stake in whether somebody is detained in a hospital by a court order. In fact, without a court order it is an unlawful detention subject to both criminal and civil penalties.  Over the years I have had to discharge many people because the court did not produce a timely court order or decided to release the patient.  Further, in the actual hearing the opinions of the court examiners are the ones the judges depend on. The only interest of the inpatient psychiatrist is making an accurate assessment, making sure all of the patient’s medical problems are treated, and making the optimal recommendations for medical and psychiatric care. The inpatient psychiatrist is also talking with the patient on a daily basis assessing progress and attempting to establish a good working relationship with the patient whether or not a court hold is in place or not. That working relationship is possible when the patient recognizes that there is no adversarial relationship with the inpatient psychiatrist. In fact, the treatment of patients on court holds should be indistinguishable from voluntary patients.

By Schramme’s formulation that patient is not a competent consenter. As noted about his passive cooperation with the burn surgeons, endocrinology, and the inpatient psychiatrist might be construed as interactive coercion. There is also a chance that it might not be according to these definitions because the psychiatrist is discussing adverse outcome with the patient but the discussion is based on what has happened many times already.  Even with compromised cognitive capacity the patient is able to acknowledge this and the fact that he does not want to end up in a coma in the ICU gain. Another important aspect of these discussions is the psychiatrist is very neutral and not reactive or blaming. They are a sincere expression of concern given everything that is going on an what has happened to the patient.

A final consideration here is that both philosophical and legal approaches to involuntary treatment probably do not capture what is really happening. For example the will  or the autonomous will is the focus of both the coercion and the involuntary treatment discussion.  Reading though any paper on the will, illustrates that it is a vague, changeable, and completely subjective concept.  It is also not constant over time. When philosophers like Schramme write about it – the are typically referring to an individual and not a class of people. It makes more sense to talk about a person’s conscious state rather than an isolated will.  Conscious states are complex and multidimensional (6).  Even though they cannot be accurately measured at this point – on a clinical basis it can easily be observed that conscious states can change from being adept at self-care and day to day living to states where inadequate self-care becomes self-endangering. It makes very little sense to think that the will or autonomous will of a person experiencing a major psychiatric illness is constant over time. The goal of treatment ideally is to restore the autonomous will and assist the patient with getting back to their baseline.  I have had that confirmed many times by people who benefitted from that process.

 

George Dawson, MD, DFAPA  

 

References:

1:  Bureau of Labor Statistics. Occupational Employment and Wages, May 2020 29-1223 Psychiatrists https://www.bls.gov/oes/current/oes291223.htm

2:  Schramme T.  Coercive threats and offers in psychiatry. In. Schramme T, Thome J (eds). Philosophy and Psychiatry. Walter de Gruyter; New York; 2004: 357-369.

3:  Gutheil TG, Appelbaum PS.  Clinical Handbook of Psychiatry and the Law, 3rd edition. Lippincott, Williams, and Wilkins, New York; 2000; p. 153-162.

4:  Szmukler G, Appelbaum PS. Treatment pressures, leverage, coercion, and compulsion in mental health care, Journal of Mental Health. 2000 17:3, 233-244, DOI: 10.1080/09638230802052203

5:  Walter J. Consciousness as a multidimensional phenomenon: implications for the assessment of disorders of consciousness. Neurosci Conscious. 2021 Dec 30;2021(2):niab047. doi: 10.1093/nc/niab047. PMID: 34992792; PMCID: PMC8716840.

 

Supplementary 1:  Workforce exposed to involuntary treatment scenarios:

There are an estimate 30,451 working psychiatrists in the United States. According to the Bureau of Labor Statistics 25,540 are employed and the rest are self-employed.  Since it is very likely that acute care psychiatrists are employed by hospitals 4,160 are in General Medical and Surgical Hospitals and 3,550 are in Psychiatric and Substance Use Hospitals. There are currently 37,400 members in the American Psychiatric Association and that number may reflect researchers and the retired.  The total pool of psychiatrists who might be involved at some level in involuntary treatment is about 7,710 from the acute care setting but that is likely a gross overestimate for several reasons. First, not all acute care settings treat people on an involuntary basis. In any metro area emergency medical services (EMS) generally brings the patients to only those hospitals who can provide the full array of emergency services. Second, even among psychiatrists employed in hospitals only a small percentage of them will provide direct care to patients who are there on an involuntary basis. Third, there are very few free-standing psychiatric hospitals or substance use facilities that accept anyone on an involuntary basis. It is very likely that less than 10% of the psychiatric workforce ever provides treatment to people on an involuntary basis.   

Supplementary 2: Graphic modification to show the emergency hold and probate court hold





Supplementary 3:  Historical note

Although the patient is clearly safeguarded in the above process - some people might ask themselves: "Why don't we just abolish involuntary treatment and let things revert back to the way it was?"  It would certainly make things a lot easier for psychiatrists. The short answer is that it is inhumane to people with severe mental illness and their families.  The families are typically omitted from any discussion of involuntary treatment but historically they were charged with trying to contain a family member with severe problems.  Patients in those situations often had catastrophic outcomes and even if they did not entire generations of family members were adversely affected by single family members with severe mental illness.  That history is out there but it is difficult to find probably because of the stigma associated with those disclosures.