The Cardiac Ablation

 

On August 30, 2023, I finally bit the bullet and had a cardiac ablation for atrial fibrillation and atrial flutter. If you are one of those rare readers of this blog you may recall me wrting about it and how it occurred in the first place. I happened to be speedskating 19 years ago on the John Rose Oval and just completed my warm up laps.  I looked at my heart rate monitor and my pulse was 170 BPM.  I pulled up to stretch a little and suddenly my HRM was chirping irregularly and the rate was 240 BPM. I checked my carotid pulse and knew I was in atrial fibrillation. I drove down to the hospital where I was cardioverted with flecainide and metoprolol and have been taking those medications ever since.

In the interim, I have seen a sports cardiologist several times, 5 electrophysiologists (EP), and two general cardiologists as well as my primary care physician and the physicians that cross cover for him. I have also been seen in the emergency department for a heart rate that was down to 25 beats per minute and atrial bigeminy. The physician in the ED thought that I might need a pacemaker, but it turns out that the combination of flecainide and metoprolol can cause significant bradycardia. Once I learned that I started cutting 25 mg tablets into quarters (6.25 mg) and would typically take two of those tablets per day. I also learned that if you take flecainide, you also need to take a beta blocker or a calcium channel blocker to prevent atrial flutter.  Atrial flutter is difficult to diagnose without an ECG because clinically it can seem like sinus tachycardia.  For example, I have had the flu or taken corticosteroids for asthma and developed tachycardia.  When I started running rates of 130 bpm, that seemed a little high for sinus tachycardia.  I decided to get an ECG and it was atrial flutter. I had to figure all of that out, because my initial plan was to taper off metoprolol and that is unrealistic.

At the same time, the combination at times would cause severe bradycardia.  I had a nocturnal heart rate of 35 BPM recorded on a Holter monitor and saw a cardiologist.  We agreed to stay at metoprolol 6.25 mg BID unless there were extraordinary circumstances.  That generally works but my heart rate can still get into the 40s range. That led me to the stage to consider the ablation.  The other factor is that the second EP cardiologist that I saw 15 years ago told me to wait on an ablation because the technology was not good enough. When I saw him this Spring – he thought it had matured and recommended the procedure. He also told me that both the atrial fibrillation and atrial futter could be ablated in a single session rather than two and that was the first time I heard that. 

For about 15 years I have been titrating what most people consider to be microdoses of metoprolol (Physicians typically say: “I have never heard of a dose that small.”) against the flecainide and it has been holding very well. I get about 1 major episode of afib per year that may last 2-3 hours.  I typically take the next dose of flecainide and 12.5 of metoprolol instead of 6.25.   Multiple 24 hr Holter monitors and clinical assessments by cardiologists have not resulted in a better combination.  They were adamant about not increasing the flecainide because of the risk of QRS prolongation and ventricular arrythmias.  There was a consensus to try the ablation – even if the pandemic had persisted.

Researching the procedure followed three lines of evidence.  The first was efficacy and that seems to be a moving target. Conventional wisdom for a long time was that rate control (maintaining a heart rate of < 100 bpm even if you were in atrial fibrillation) and rhythm control (maintaining normal sinus rhythm) produced equivalent results. It turns out that is true only if hemodynamic stability is maintained and for some people it is not.  When that happens, they develop significant symptoms like shortness of breath, lightheadedness, dizziness, chest pain, and can even develop congestive heart failure and renal failure. When all of that is not planned it is riskier to stabilize the person. There is also concern that rate control leads to quality-of-life (QoL) problems associated with both the direct symptoms and indirect symptoms like anxiety about palpitations and the arrhythmia. There seems to be movement in the direction of an attempt to stabilize the rhythm with medication and if that fails try the ablation. There is a QoL rating scale available for atrial fibrillation.  In terms of likelihood of ablating the arrhythmia the frequent quotes are generally 2/3 to ½ of patients, but the data is complicated by the number and intensity of cardiac morbidities.

The second line of evidence was complications and serious complications were noted.  Radiofrequency ablation of arrhythmias in some cases produces a full thickness burn to the heart muscle.  As a result, it can damage adjacent structures including the esophagus and the phrenic nerve.  It can also lead to pericardial effusions and cardiac tamponade. In a very worst-case scenario atrial-esophageal fistula with gas in the left atrium and left ventricle essentially causing an air lock in the pumping mechanism of the heart (4).  

The third line was something I had not considered in the past and that is that atrial fibrillation is progressive. In other words, even if you have good rhythm control with medication, unless something is done to alter the electrical substrate the likelihood of maintaining a normal sinus rhythm after an ablation decreases over time. Accumulating cardiac problems outside of atrial fibrillation can predispose to the condition and make it harder to treat.  

Some additional intangibles were considered. I would like to get back on the ice speedskating. That will take rhythm control and some resilience against exercise induced tachycardia.  Rhythm control is important because atrial fibrillation reduces typical cardiac output by 20-30% based on inadequate filling and pumping cycles due to the irregular heartbeat.   Augmentation of ventricular filling is also adversely affected due to a lack of coordinated atrial contractions.  I am hoping the ablation gets me close to that goal.  There are some theories that interoceptive signaling in the form of accelerated heart rate from any cause can lead to anxiety.  Certainly many people with arrhythmias have anxiety that may seem explainable on a general medical concern basis but there may also be an autonomic component as well as a cognitive component based on the multiple concerns of treating a chronic disorder than can cause stroke and congestive heart failure.    

What has happened so far? I underwent the procedure.  It was 4 hours and 40 minutes in duration from intubation to extubation. The general anesthesia given is shown in the graphics below. The top graphic is the one I made until the official graphical anesthesia record could be located as the second graphic. To do the ablation 4 catheters were placed in the right femoral vein and one in the left. I don’t know the technical details of those catheters only that one is for cryoabalation/isolation of the pulmonary veins in the left atrium, one is for mapping the electrical fields in the surrounding tissue, and one is for a radiofrequency ablation of the a CTI line (cavotricuspid isthmus) in the the right atrium.  That procedure targets atrial flutter.  The plan was do the CTI line ablation first and then puncture the interatrial septum and then enter the left atrium with the cryoablation catheter for the pulmonary vein isolation.  The technical details are more complex since the ablation sites and surrounding areas need to be checked to makes sure that the abnormal conduction sites have been eliminated and no new pathways are evident. The phrenic nerve and esophagus are also checked to make sure there is no damage from ablation that occurs in proximity to these structures. 

Everything seemed to go well during the procedure.  There were no obvious complications just a long time under general anesthesia. Recovery room was uneventful but they decided I needed to stay overnight to monitor bleeding risk from the catheterization site.   That happened when they got me up at the 6-hour mark – blood from the largest site in the right groin dripping onto the floor. More pressure applied and the bleeding stopped and I was discharged the next day.

I tried to capture the post-procedure course by in the following graphics.  In clinical practice it was common for me to see people of all ages who had ablations for various arrhythmias. In some cases, they were told to “go home and throw your medications away!” as a result of the ablation.  That may apply to some arrhythmias but not atrial fibrillation. They told me to expect no changes in the medications for 3 months and that I would be taking the same doses of metoprolol and flecainide.  Later at the time of discharge – they told me that in some cases there is a very rocky course until things heal up from the procedure and that it was not uncommon for people to get palpitations and even a return of the rhythm problems.

As noted in the graphics – the course to date has been rocky.  At this point much more atrial fibrillation than I have experienced in the past 16 years and much longer duration.  In my reading about why athletes get atrial fibrillation and the associated experiment work in that area – running sustained high heart rates causes remodeling of the biological substrate of the heart and that makes continued atrial fibrillation more likely. In 16 years, I rarely had an episode that lasted longer than 2 hours and lately more seem to end in less than an hour. As I type this today, I have been in atrial fibrillation for going on 48 hours continuously and just this morning converted to a rapid ventricular response meaning that my ventricular rate is the same as the atrial rate of 150 bpm.  Estimated maximum heart rate for exercise at my age is about 130 bpm.

As can be seen from the graphic there are additional unexpected side effects primary among which is ocular migraines.  An ocular migraine is a typical migraine scotoma without a headache. It starts out as a small shimmering spot or disk in the visual field and slowly expands to a large, jagged, shimmering circle of light. Within about 20 minutes it is gone. Unlike a retinal detachment or stroke there are no deficit symptoms like permanent blind areas in the visual field.  When I asked several staff people about the cause they attributed it to general anesthesia however it is well documented to occur with congenital defects in the atrial septum (patent foramen ovale or PFO) and iatrogenic defects of the septum caused by catheterization into the left atrium (7-10).  Repair of the defect in some cases reverses the headache. About 75% of the iatrogenic atrial septal defects (ASD) spontaneously close by 12 months.  UpToDate put the risk of persistent ASD at 5-20% at 9-12 months (16).

A critical question for anyone contemplating an ablation procedure on a non-acute basis like I did is the post operative course. I was very aware of the low frequency serious and lethal complications, but not the specific about length of time to recovery and what the symptoms might be.  Most people experience significant if not disabling symptoms for months rather than days or weeks following the procedure. That is based on a small study where they did detailed interviews on what happened to the subjects following the ablation (11).  It is available to read online and I would encourage anyone interested in the procedure or knowing more about the procedure to read it.  One of the authors' conclusions is  

“The majority (85%) of the study sample did improve at six months, but the process was much slower and more difficult than expected. Although the symptom burden post-ablation did decrease over the six months, only 50% of subjects (n=10) were symptom-free and off anti-arrhythmic medications at six months.”  (reference 11)  These findings are qualified by the study sample size as well as the possibility of selection bias since the researchers were looking for people who could tolerate the protocol of completing rating scales and lengthy interviews about potential adverse events.  Reference 11 is also very useful in terms for what kind of recovery time to expect - especially in terms of fatigue and more frequent contact with the healthcare system after atrial fibrillation ablation (12).

That is certainly consistent with my experience. Right at this moment I have been in atrial fibrillation or atrial flutter continuously for 48 hours.  My heart rate is 160 bpm at rest.  I am contemplating taking more medication on my own initiative or going to the ED for cardioversion. I am scheduled for a cardioversion in the cardiology clinic on Wednesday September 13 - but I don't know if I can hold off that long.   I guess I am hoping for a break. There are many mitigating factors. Whatever happens tonight – I hope to add more to this post soon.  This is an important topic that has been neglected for too long.

Final qualifier on this post to point out that this is my experience and it does not mean it would be your experience. Much of the sensationalism about medicine in the media is based on oversimplified dichotomous thinking.  Medications, procedures, tests, doctors and even diagnoses are seen as all bad or all good.  Human biology is very complex and there are few if any medical interventions that address that level of complexity. That typically means that over any population there will be an array of outcomes and most of them will not be explainable. That is a hard pill to swallow but that is the state of the art of modern medicine. 

 

George Dawson, MD, DFAPA

 

Supplementary 1:  Cardioversion today (9/13/2023) successfully terminated about 90 hours of atrial fibrillation (rates of 70-140 bpm) with atrial flutter (rates of 150-160 bpm).  In terms of the original ablation procedure that is probably more hours of these arrhythmias than I have experienced in the past 19 years.  Normal sinus rhythm has been present for the past 10 hours and vital signs are normal.  What follows is a graphic of the entire process starting with the ablation and ending with the cardioversion. There were multiple episodes of atrial fibrillation before it became continuous with shift to atrial flutter.  During the 90 hours most of the rates were 150-160 bpm.  That is consistent with atrial flutter and may have been associated with a change in medications.

Supplementary 2:

The discussion leading up to the ablation:

https://real-psychiatry.blogspot.com/2022/11/a-visit-to-electrophysiologist.html

 

Image Credit:

Click to enlarge any graphic.

Rottner L, Bellmann B, Lin T, Reissmann B, Tönnis T, Schleberger R, Nies M, Jungen C, Dinshaw L, Klatt N, Dickow J, Münkler P, Meyer C, Metzner A, Rillig A. Catheter Ablation of Atrial Fibrillation: State of the Art and Future Perspectives. Cardiol Ther. 2020 Jun;9(1):45-58. doi: 10.1007/s40119-019-00158-2. Epub 2020 Jan 2. PMID: 31898209; PMCID: PMC7237603.

License : https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Image is used "as is" from the paper and no changes were made.  

Remaining images were all generated by me.

Hat Tip:  Kenneth A. Vatz, MD - a neurology colleague on Twitter who analyzed the scotoma symptoms and directed me to excellent references connecting atrial septal defects to migraines and scotoma especially reference 10. 

Hat Tip:  Medical records staff at Regions Hospital who persevered, located the graphical anesthesia record and mailed it to me on 9/19/2023.  I just incorporated it into this post today.  I have a similar request into the electrophysiology staff so that I can display the actual mapping of this procedure but have been advised that they are less likely to provide these images.     

Update (11/22/2023):  I had a brief (20 min) episode of atrial fibrillation this AM that resolved spontaneously.  It was rate controlled at about 84 BPM.  It is the only arrythmia I have had since the 4 days of atrial flutter early in September.  I notified the clinic and emailed them a tracing of my Kardia ECG.  I have a scheduled appointment next week and it was supposed to be to taper and discontinue the antiarrhythmic medications.  Also seem to correlate with progressively lower HRV numbers despite more vigorous workouts and higher heart rates.

References:

1:  Alobaida M, Alrumayh A. Rate control strategies for atrial fibrillation. Ann Med. 2021 Dec;53(1):682-692. doi: 10.1080/07853890.2021.1930137. PMID: 34032538; PMCID: PMC8158272.

2:  Barbero U, Ho SY. Anatomy of the atria : A road map to the left atrial appendage. Herzschrittmacherther Elektrophysiol. 2017 Dec;28(4):347-354. doi: 10.1007/s00399-017-0535-x. Epub 2017 Nov 3. PMID: 29101544; PMCID: PMC5705746.

3:  Lim HS, Schultz C, Dang J, Alasady M, Lau DH, Brooks AG, Wong CX, Roberts-Thomson KC, Young GD, Worthley MI, Sanders P, Willoughby SR. Time course of inflammation, myocardial injury, and prothrombotic response after radiofrequency catheter ablation for atrial fibrillation. Circ Arrhythm Electrophysiol. 2014 Feb;7(1):83-9. doi: 10.1161/CIRCEP.113.000876. Epub 2014 Jan 20. PMID: 24446024.

4:  Thomson M, El Sakr F. Gas in the Left Atrium and Ventricle. N Engl J Med. 2017 Feb 16;376(7):683. doi: 10.1056/NEJMicm1604787. PMID: 28199804.

5:  Manolis AS. Transseptal Access to the Left Atrium: Tips and Tricks to Keep it Safe Derived from Single Operator Experience and Review of the Literature. Curr Cardiol Rev. 2017;13(4):305-318. doi: 10.2174/1573403X13666170927122036. PMID: 28969539; PMCID: PMC5730964.

6:  Singh SM, Douglas PS, Reddy VY. The incidence and long-term clinical outcome of iatrogenic atrial septal defects secondary to transseptal catheterization with a 12F transseptal sheath. Circ Arrhythm Electrophysiol. 2011 Apr;4(2):166-71. doi: 10.1161/CIRCEP.110.959015. Epub 2011 Jan 19. PMID: 21248245.

7:  Kato Y, Hayashi T, Kato R, Takao M. Migraine-like Headache after Transseptal Puncture for Catheter Ablation: A Case Report and Review of the Literature. Intern Med. 2019 Aug 15;58(16):2393-2395. doi: 10.2169/internalmedicine.2519-18. Epub 2019 Apr 17. PMID: 30996181; PMCID: PMC6746642.

8:  Hoshina Y, Iijima H, Kubota M, Murakami T, Nagai A. Case of atrial septal defect closure relieving refractory migraine. Clin Case Rep. 2022 Nov 6;10(11):e6484. doi: 10.1002/ccr3.6484. PMID: 36381060; PMCID: PMC9637252.

9:  Azarbal B, Tobis J, Suh W, Chan V, Dao C, Gaster R. Association of interatrial shunts and migraine headaches: impact of transcatheter closure. J Am Coll Cardiol. 2005 Feb 15;45(4):489-92. doi: 10.1016/j.jacc.2004.09.075. PMID: 15708691.

10:  Schwedt TJ. The migraine association with cardiac anomalies, cardiovascular disease, and stroke. Neurol Clin. 2009 May;27(2):513-23. doi: 10.1016/j.ncl.2008.11.006. PMID: 19289229; PMCID: PMC2696390.

11:  Wood KA, Barnes AH, Paul S, Hines KA, Jackson KP. Symptom challenges after atrial fibrillation ablation. Heart Lung. 2017 Nov-Dec;46(6):425-431. doi: 10.1016/j.hrtlng.2017.08.007. Epub 2017 Sep 18. PMID: 28923248; PMCID: PMC5811184.

12:  Wood KA, Barnes AH, Jennings BM. Trajectories of Recovery after Atrial Fibrillation Ablation. West J Nurs Res. 2022 Jul;44(7):653-661. doi: 10.1177/01939459211012087. Epub 2021 Apr 26. PMID: 33899608; PMCID: PMC8801207.

13:  Björkenheim A, Brandes A, Magnuson A, Chemnitz A, Svedberg L, Edvardsson N, Poçi D. Assessment of atrial fibrillation–specific symptoms before and 2 years after atrial fibrillation ablation: do patients and physicians differ in their perception of symptom relief?. JACC: Clinical Electrophysiology. 2017 Oct;3(10):1168-76.

14:  Dorian P, Angaran P. Symptoms and Quality of Life After Atrial Fibrillation Ablation: Two Different Concepts. JACC Clin Electrophysiol. 2017 Oct;3(10):1177-1179. doi: 10.1016/j.jacep.2017.06.007. Epub 2017 Sep 13. PMID: 29759502.

15:  Steinbeck G, Sinner MF, Lutz M, Müller-Nurasyid M, Kääb S, Reinecke H. Incidence of complications related to catheter ablation of atrial fibrillation and atrial flutter: a nationwide in-hospital analysis of administrative data for Germany in 2014. Eur Heart J. 2018 Dec 1;39(45):4020-4029. doi: 10.1093/eurheartj/ehy452. PMID: 30085086; PMCID: PMC6269631.

16:  Levy S.  Overview of catheter ablation of cardiac arrhythmias.  In: UpToDate, Connor RF (Ed), Wolters Kluwer. (Accessed on January 17, 2023) 

 

 

Happy Labor Day 2023!

 

Over the years of writing this blog I have put out a Labor Day message to describe any progress in the physician workspace in the past year.  The practice environment for physicians has deteriorated significantly over the past 3 decades and those changes are generally locked in by the healthcare business managers backed by both Congress and state governments. I have used the following graphic several times on this blog to illustrate what happened over specific time frames and it is probably time to add some additional details.

The impact of managed care on medical practice has been clear for the past 30 years.  In many cases that model is being adopted by physicians in private practice settings. For example, it is common now to see a specialist initially but in follow up see one of the physician extenders working with them. That can make health care a lot less personal and it leads me to think about the reason why physicians are trained to provide continuity of care in the first place.

But even more than that issue is the explosion of online services provided for flat rates that focus on seemingly basic problems in exchange for payment. On my streaming services that typically involves a company that offers prescriptions for depression, anxiety, hair loss, and erectile dysfunction.  A second company offers beta blockers for performance anxiety.  Given the side effect potential for these medications – I am curious about how comprehensive the initial evaluations are and the follow up visits.

I was recently hospitalized and had a first hand look at what the modern hospital workplace looks like.  When I was in training there were discrete teams by specialty and they consisted of physicians at all levels of training.  A typical team might have 1-2 med students, 1-2 interns, a resident, a senior resident or fellow, and the attending. The work load would depend on whether your service admitted people to the hospital (typically internal medicine, surgery, neurology, renal medicine, cardiology, psychiatry) or consulted to those teams (infectious disease, endocrinology, pulmonology, rheumatology, cardiology, psychiatry).  The admitting services were the most intense because of irregular admissions and complicated unstable patients. Teams generally had places to meet, where patients were presented to the attending and there were formal didactics. Bedside teaching occurred on rounds.

During my hospitalization, I was not seen by a single physician in my room. When I went out into the hallway, both sides of the hall were lined by people facing computer screens. There was one consulting team standing outside a patient door – visible only because it was obvious the fellow and attending were discussing cases. The level of crowding was striking and it left me with the impression that all these people could not possibly be physicians.  Managed care shaped the form of these teams and who was in that hallway. First, they eliminated the usual admitting services and replaced them all with hospitalists. Then they replaced at least some physicians on those teams with non-physicians. Those moves benefit business decisions but I have not seen a single adequate study on the impact it has on medical care.

Training physicians in hospitals has typically involved hands on learning, consultation from senior and expert physicians, and active learning environment, and in many cases the opportunity for research.  All these areas need to be preserved in the practice environment in order to stimulate practicing physicians to maintain high standards. An environment that leads to burnout, sleep deprivation, and moral injury is not adequate to the task. The question always has been whether physicians have any kind of leverage that could lead to appropriate modifications. That question has never been put to the test and in fact, healthcare organizations in the United States generally flaunt their power over physicians rather than attempting to negotiate with them.

Will a union make a difference? My experience with unions started out in my family of origin.  My father was a member of the Brotherhood of Locomotive Firemen and Engineers (BLFE). He worked as a locomotive fireman and then an engineer.  He had to be a union member in order to work.  He generally was not very happy about it. The railroad industry was run on a seniority system and as railroad utilization decreased – younger workers like my father had a difficult time finding job assignments. Even though they were technically employed by a railroad and reimbursement for the work was good, it seemed like only the most senior engineers benefitted to the point that they could make a good living.  As a result, the contracts negotiated by the unions did not mean that much to my father. He also tended to see the union as corrupt because, the union officials clearly made far more than he was making trying to work in their system.  Railroads unions were also compartmentalized - so a strike against one railroad did not mean a strike against all.  As a result, workers from the railroad that was the object of the strike could work for competing railroads during the strike. If similar rules apply to physicians a uniform practice environment is no guarantee, but the onerous aspects might be eliminated.   

Unions for physicians and residents are becoming increasingly popular but they have more restrictions that in a blue-collar environment. The National Labor relations Board (NLRB) enforces the National Labor Relations Act (NLRA) and decides what public sector employees can form unions (1). Independent contractors, supervisors, and managers are excluded because the focus of the act was on laborers. The general categories are loosely defined so it takes an NLRB investigation to determine who can be in the union. Tenure and tenure track employees were eliminated by a Supreme Court ruling. Only salaried employees who do not do a significant amount of supervision are allowed to be union members. If a union is allowed, the goals in terms of collective bargaining, representation, and impact on hospital policies need to be determined.  Although the momentum for unions is building, there is a considerable amount of inertia from the managed care era. During that time, we had many physicians who were eager to escape a deteriorating practice environment to become administrators and basically enforce business policies. It remains to be seen if unions can have a favorable impact on local health care policy and practices – but just establishing more is a step in the right direction.    

More resistance to Maintenance of Certification by various boards and the American Board of Medical Specialties is also growing. I went to the alternate system National Board of Physicians and Surgeons (NBPAS) certification in 2018 and have not looked back. At the same time, I realize that I was outside of any system demanding that I recertify through an ABMS board and as a result – in a unique situation relative to younger colleagues. A petition was started in July to end ABMS MOC and so far there are 20,000 + signatures. There was an initiative in the APA to stop MOC about 10 years ago, but the administrative process prevented it from being put on a ballot. The basic problems with MOC is that there is no evidence it is necessary for quality care, in fact most health care organizations have abandoned true quality programs. Second, it is not reflective of clinical practice. Most physicians – even generalists end up in a niche and focus their educational efforts and mastery in that area. It makes no sense to keep taking examinations outside of that area. Third, it is a substantial time and financial commitment and it clearly generates a lot of revenue for ABMS specialty boards. Fourth, there is some suggestion that MOC should be tied to state licensing (Maintenance of Licensure or MOL). This would allow states and health care organizations even more power in controlling physicians – even during their private times when they would need to spend time studying for barely relevant examinations. Elimination of MOC is another positive step in the direction of restoring a more reasonable practice environment.

Beyond a better practice environment and what it takes to make that politically – the profession of medicine is at stake.  I have written about a lot of the technicalities – but this is deeply personal. Going to medical school and studying medicine was the best thing I could have done with my life. By identifying with the practicing physicians in my various training programs I learned how to live and breathe medicine and psychiatry 24 hours a day. Always thinking about it, never far from a journal article that I wanted to read, and always focused on how that translated to clinical practice – usually a very hard problem I was seeing in practice. From the very first patient contact, the importance of communicating with people in an empathic, unhurried and comprehensive way was obvious.  We cannot afford to lose that transformative effect that medicine has on people.  We cannot dumb things down for the business world and make human biology less complex. I know there are many docs out there that think like me.  Whether we can unionize or cancel MOC – we can never lose sight of the fact that we need to preserve a transformative profession for the sake of future generations of physicians and their patients.

 

 

George Dawson, MD, DFAPA

 

References:

1:  Bowling D 3rd, Richman BD, Schulman KA. The Rise and Potential of Physician Unions. JAMA. 2022 Aug 16;328(7):617-618. doi: 10.1001/jama.2022.12835. PMID: 35900755. 

The True Big Pharma Backers Show Themselves

 

Here is a hint – they are not psychiatrists or even physicians.  They are Republicans.  That may come as a shock to those of you who have absorbed all of the pharma conflict of interest stories about physicians over the past 20 years. Psychiatry in general was selected for much of that criticism. The average physician in the US had no significant conflict of interest even when trivial compensation like meals during continuing medical education (CME) courses were tallied. Some members of Congress even went so far to investigate some psychiatrist’s personal employment arrangements to point out any potential conflicts of interest when it came to pharmaceutical manufacturers.

Today we finally have some clarification on who really backs Big Pharma and wants to assure their large profits.  It should come as no surprise that it is Congress – specifically members of the pro-business GOP.  For years, Congressional conflict-of-interest has been sanitized by their disclosures as if that somehow prevented them from passing pro-Pharma legislation and regulations. For the record the amount of lobby money to the major parties varies from year to year.  For 2022 a total of $26,297,445 was donated from the pharmaceutical industry with $15,175,518 to the Democrats and $10,994,723 to the Republicans. That is an average donation of $29,159 to $105,910.  By contrast the Open Payments site recording payments to health care professionals claims that drug and medical device companies gave physicians $12.59 billion in 2022, but they are counting funds used to pay for research as well as profits from ownership of patents and medical devices (a total of $8.87 billion).  Looking at general payments alone, the physicians receiving any type of reimbursement averaged about $441. The current reporting rule is that any amount exceeding $10 or an aggregate of $100 in the case of meals must be reported.

I previously asked the question whether a slice of pizza given to a doctor at grand rounds was more likely to get results for the pharmaceutical industry than the average donation to Congress ($46,579 at the time).  I made the point that despite the continuous criticism of psychiatrists, they happen to be way down on the list of physicians getting these donations with about 37% receiving general payments and 3.6% receiving payments totaling more than $10,000.

But all the corruption by trivial payments discussion was based on shaky research. It is quite easy to demonstrate that physicians want to try new drugs as they come into the marketplace and show that marketing efforts correlate with prescriptions. We had a No Free Lunch movement to prevent corruption by pizza slices. We had a great deal of agitation about ghost writers, pharmaceutical companies not publishing negative studies, faulty research, side effect reporting, etc. Almost all of that involved psychiatry and often several self-appointed critics from the field.  There are undoubtedly problems with clinical trials in all specialties, but during that 20-year span from about 1998-2018 it seemed as if there was an active conspiracy to sell psychiatric medications.  To some extent that continues but it has less legitimacy in the field particularly since drug detailing and sales have been eliminated from most clinics and hospitals.

All of that commotion was probably good cover for Congress who was actually receiving payments that could make a difference.  And during that time pharmaceutical companies recorded record profits.

What is different now?  The Biden administration has decided that it wants to negotiate prices for Medicare Part D prescriptions. They are on solid ground. The Veterans Administration (VA) negotiates drug prices and has 399 drugs on their formulary.  A GAO study showed that they paid 54% less per unit than Medicare. HHS has already selected the drugs that will be negotiated in the initial round and as expected most of them are the high expenditure drugs in the plan.

The Republicans claim that these negotiations will decrease access to care and raise drug prices although there is no evidence that the VA negotiations have done that. They also claim that there will be reduced innovation, research and development, and job losses. They seem to have missed the overall picture that pharmaceutical companies in other countries succeed – even when there are negotiated prices with the health plan in those countries. Of the top 15 pharmaceutical companies in the world 8 are in the United States and the remainder in Switzerland, UK, France, Denmark, and Japan. The numbers given for fewer new drugs, fewer new indications, and drop in R&D spending seem highly speculative to me.  For example, the drop of $663B in R&D spending is the equivalent of about half of the total revenue for the top 15 companies.   I seriously doubt they are spending that much on R&D. During the 20 year period that I am referring to companies left entire therapeutic areas and it was common knowledge that marketing was going to drive pharmaceutical sales. There is an entire section about decreased jobs.  Are the Republicans really suggesting that Americans should pay (by far) the highest amounts for prescription drugs in order to fund a jobs program? And finally, the suggestion that the plan is “legally dubious”.  Apparently Congress is set up to help industries optimize profits rather than protect people who can’t pay a thousand dollars or more for a Medicare Part D copay.         

This post also has implications of pharmacy benefit managers or PBMs.  You remember them?  They are the business entities charged with “managing” your pharmacy benefits allegedly to make medications most “cost effective”.  PBMs make about $315 B annually for doing nothing more than managing prescription drug programs for employers and other large entities with health insurance programs. In practice they are a price multiplier rather than a price reducer.  PBMs control the spread or difference between what the insurance pays for a medication and what they reimburse pharmacies. In some cases, their reimbursement for pharmacies is lower than the actual cost of the medication. Since they are leveraging large number of patients, local pharmacies typically do not have much of a choice if they expect to do business – even though an affiliation with a PBM is draining. PBMs can own their own pharmacies and reimburse those pharmacies more than community pharmacies.   For a physician the most onerous aspect of PBMs occurs with prices for drugs and their positions on formularies for hospitals and clinics.  A formulary is a restricted list of medications available for physicians in that health plan to prescribe for their patients.  That can mean a patient has to change their prescription for it to be covered or some newer medication may not be covered at all.  During negotiations with manufacturers, PBMs can get a rebate from the manufacturer if they get their product exclusively in the formulary. That rebate is kept by the PBM rather than shared with the people paying for the drug.  

The pharmaceutical landscape is a minefield that is set up to optimize corporate profits. Pharmaceutical companies are essentially guaranteed high margins based on patent exclusivity and high prices.  PBMs generate a lot of revenue, add no value, and many pharmacists would add are a drain on their businesses. Let's face it - these businesses like most of healthcare in the US were essentially invented in Congress.  If they are not a recipe for making money - I don't know what is.  The Medicare Part D price negotiations through the Inflation Reduction Act is the first bright spot I have seen in a long time.  Republicans clearly want to maintain the status quo and that means extremely expensive medications and copays for anyone who is in the Medicare Part D coverage gap. If you were ever surprised by one of these copays like I was recently – support the Biden Administration’s attempt to control high drug prices.

George Dawson, MD, DFAPA

Supplementary 1:  An obvious point that I forgot in the original post in terms of backing Big Pharma is the idea that any physician would back limited access to a needed medication because of financial (rationing) restrictions.  Toward the latter half of my career, if anything physicians have made extraordinary efforts to get medications for their patients including having to manage large collections of samples and try to supply some patients from those samples.  Incredibly - some critics saw that as another perk from pharmaceutical companies that was corrupting physicians.  Some politicians on the other hand who are getting very large donations from pharmaceutical companies have no hesitation in suggesting that American patients should continue to pay exorbitant costs for pharmaceuticals - even if it means not being able to afford medication and compromised health.   

Supplementary 2:  Must watch video on regulatory capture or how Congress profits from disrupting free markets and establishing monopolies. Pharma and electronic health record (EHR) companies are cited examples, but there are additional examples including broadband and AI:

 https://www.youtube.com/watch?v=F9cO3-MLHOM

  

The Donut Hole Gets Real

 

Like most people my age I am taking some medications regularly and got the text message today from my pharmacy that I could pick up one of those prescriptions. The medication is a commonly prescribed medication from a group of medicine called  Non-Vitamin K antagonist oral anticoagulants or NOACs.  The medication is apixaban or Eliquis. People commonly take it to prevent blood clots or emboli and the complication including stroke, thrombosis, and pulmonary emboli. I have been taking it for about 2 years.

I usually get a prescription for 180 – 5 mg tabs and the last time I picked it up was on May 25, 2023.  At that time there was a copay of $94.  I am on Medicare A and B and a Medicare Supplemental Policy.

This time as I drove through the line the pharmacist told me the copay was $500. I asked him to clarify what had happened, but he had no idea.  Even though I had all of my previous refills at this pharmacy he had no idea what had happened and advised me to call the insurance company. When I got home that is exactly what I did. They advised me that this was the standard coverage gap for prescription drugs also known as the donut hole.  The insurance company pays for $4660 worth of medication (in my case almost all apixaban) and at that point copays stop and the patient is responsible for a flat 25% of the total cost of the medication or the $500).  When the patient incurs a total of $7,400 in pharmaceutical costs the number falls to 5% of the total, but by then it is probably a new year and the running tally resets. The customer service rep told me that I might be able to apply for assistance through company or state program, but they all had low-income requirements.

The donut hole started in 2006 as a result of the Medicare Prescription Drug, Improvement, and Modernization Act of 2003. All Medicare Part D plans have it. It initially required patients to pay 100% of the drug cost during the coverage gap.  That was reduced to the current 25% by the Affordable Care Act (ACA) passed in 2010. By 2025 there will be a cap of $2,000 for costs incurred in the coverage gap. 

It turns out that apixaban is number 10 on the list of 17 most expensive drugs purchased through Medicare programs.  In 2019, the average person taking it spent $7,234 for 12 refills per year and $2,172 in out-of-pocket costs.  A reform of this pricing has been suggested but obviously has not been done since I am paying about the 2019 list price.   The top drugs on this list are easily not affordable for many people. The cost of the top 5 agents are $16,348 to $182,162 per year with out-of-pocket costs ranging from $3,242 to $11,532 due to the coverage gap (1).  Apixaban in the single largest Medicare Part D expenditure at $12.5 billion per year (last filed in 2021).

Flashbacks of my work in acute care. For 22 years, I treated low to no income people in acute care settings. I was lucky to work with excellent social workers who would exhaust every available resource to help them with funding for medical care and housing.  Getting their medications funded was a chronic problem.  People on Social Security Disability do not get a lot of money each month.  At one point the state instituted a spenddown.  That meant if you were hypothetically making $1,000/month in disability payments, the state could demand that you spend a significant portion of your disability on medications before they would add any additional money for that purpose.  It is not possible to live very well – if at all under those financial constraints.

One of our attempts to adapt was to use the company scholarship programs to get them assistance from pharmaceutical companies. With many patients that took a great deal of coordination and filling out forms.  It also required nursing time for both the paperwork and an additional effort to manage free samples of medication. We were often scrambling to find medications in urgent situations or because one of the authorizations had lapsed.  All the samples also had to be catalogued by lot number in case there was a recall of that medication. I did not look forward to dealing with the forms or samples but realized we had to do it or some people would not get the medication they needed.

Today the tables were turned and I was looking at an arbitrary payment or I would not get the medication.  I have also heard this story many times. People unable to pick up a needed medication because of the copay – leading to an abrupt discontinuation or attempting to stretch out an existing medication until the first of the year. You really cannot stretch out an apixaban prescription.  I have read many news stories about people trying to stretch out their expensive forms of insulin resulting in medical compromise and death. I was lucky enough to have savings to cover the $500.

What are the problems with the donut hole?  I can think of at least 4:

1: It kicks the can down the road (also known as cost shifting). When confronted with these large payments, I can imagine a lot of people tell the pharmacist to forget about it and drive away. In the case of this medication that can lead to strokes, pulmonary emboli, thrombosis of large blood vessels, and/or death.  Treatment typically involves hospitalization and possible nursing home placement.  Worst case scenario might involve death, prolonged rehabilitation and the hospital or nursing home eventually seeks all of a patient’s assets to cover the accumulating bills.  All of those events could have been prevented with the prescribed medication.

2:  The structure of this billing is an incentive for pharmaceutical companies to increase prices since that will cause benefits to hit the wall earlier and cause the patient to enter the coverage gap and to pay more cash.  In fact, it is an obvious way to extract the maximum payment from both the insurance company and the patient. 

3:  It is another classic example of how politicians work to subsidize businesses in a non-transparent way.  I know more about medical billing than most people but I had no idea I was turning over $500 today until I was advised by the pharmacist.  

4:  This is a clear example of why the Republican and Libertarian ideas about "free market" healthcare are false.  In other words, we would choose to pay for what we really wanted in a free market and pay those market prices.  Obviously, anyone would pay $500 (or more) to prevent a stroke - but not if it means not eating.  The politicians involved will say: “well yes – but there is no free market.”  Of course, there is no free market. The market is actively manipulated to optimize profits for health care companies and minimize guidance from physicians.  That is the political system in the US. No doctor that I know of wants to prescribe a medication and hear at some point that the patient could not afford to take it. Sometime that news is very slow and the prescribing doctor does not find out until they see the patient back in a couple of months.

Don't ever think that American "free market" capitalism is a big deal in health care.  It is a big deal when politicians work with businesses to give them access to your assets and allows other businesses with more focal products like pharmaceuticals to charge whatever they want. There is no better example than the donut hole.  The cost savings that these companies promised is not from cost containment, but from rationing and that is a big difference. 

 

George Dawson, MD, DFAPA

 

References:

Dusetzina SB. Relief in Sight - Estimated Savings under Medicare Part D Redesign. N Engl J Med. 2021 Dec 23;385(26):e93. doi: 10.1056/NEJMp2116586. Epub 2021 Nov 10. PMID: 34758246.

Supplementary 1:

I downloaded this list of medication arranged by total Medicare Part D expenditure from the CMS web site on 8/26/2023.  The most recent data they have is for 2021.  Medications for psychiatric indications do not appear until # 24 Invega Sustenna and #31 Latuda.  More than a little interesting because psychiatrists have endured medication based attacks for over 20 years - primarily on grossly inflated conflict of interest concerns, pharmaceutical company profits concerns, and drug safety.  Many of those attacks continue today even though most of these medications are inexpensive generics and much of the rhetoric has lost its punch.  These same critics apparently have no similar concerns about significantly more profitable and higher risk medications.  That adds to my commentary in this post. 

Supplementary 2:  The Medicare Part Drugs selected for HHS negotiations with manufacturers include the following.    There is some overlap with the most expensive medication listed above but Farxiga, Entresto, Enbrel, and the list of diabetes mellitus medication are not on that list. For more information on the list click on the link at the bottom of the table. 

Medicare Drugs Selected by HHS for Price Negotiations

Eliquis

Jardiance

Xarelto

Januvia

Farxiga

Entresto

Enbrel

Imbruvica

Stelara

Fiasp; Fiasp FlexTouch; Fiasp PenFill; NovoLog; NovoLog FlexPen; NovoLog PenFill

https://www.hhs.gov/about/news/2023/08/29/hhs-selects-the-first-drugs-for-medicare-drug-price-negotiation.html

 

 

Graphic Credit:

Evan-Amos, Glazed Donut Public domain, via Wikimedia Commons"

Link:

https://commons.wikimedia.org/wiki/File:Glazed-Donut.jpgalt="Glazed-Donut

File:

https://upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Glazed-Donut.jpg/512px-Glazed-Donut.jpg

 

 

 

 

 

 

 

 

The Whale

I finally saw this movie as it hit my subscription networks. It is an interesting story from many perspectives that is expertly told and acted. It raises several perspectives relevant to psychiatry but thankfully that explicit connection was left out of the production.  As the final credits rolled – I noticed that it was adapted from a play.  This is the closest I would come to seeing a play.  I do not think that I am constitutionally able to watch plays. They all seem contrived, overacted, and at times require a level of immediate and shared imagination that I do not possess.  I prefer solid ground as a jumping off point – even if things go awry from there.

The stark reality of this film is the home of Charlie (played by Brendan Fraser).  We meet him as he is teaching an online course in creative writing and see a typical Zoom interface. Charlie is the only one without a visual display.  He explains that his camera is broken. The scene cuts to his home. It is a dismal setting.  We see that Charlie is massively obese, barely able to ambulate and then with great effort, and in very poor health. At one point his nurse and friend Liz (played by Hong Chau) enters and tells him that he has hypertension and congestive heart failure to the point he needs to be seen emergently or he will be dead in a few days.  His poor health is displayed many times as he starts laughing but that rapidly turns into a cough and then chest pain. Over the course of the story, we learn that Charlie was not always like this but after losing his lover Alan to suicide he began overeating and gained a massive amount of weight. We see him binge eating at several points in the film – in one case biting off a fourth of a large meatball and cheese sub sandwich and obstructing his own airway to the point that Liz had to jump on his back to dislodge the food. After chastising him she picks the remaining sandwich off the floor and hands it to him.

The food theme is prominent over the several days duration of the film. Charlie gets a pizza delivered every day and he leaves the money in the mailbox.  The delivery driver talks with him through the door and eventually they address each other by their first names. At the last delivery the driver asks Charlies repeatedly if he is OK and appears to walk away.  As Charlie opens the door, he notices the driver is off to his left looking at him and appearing mildly shocked. Neither of them speaks but Charlie goes back in the house obviously upset and binge eats the pizza along with several additional items he adds from his refrigerator.

Charlie’s self-destructive eating and the associated self-loathing is a prominent theme throughout along with the expression of disgust.  He actively seeks confirmation that he is disgusting on a physical basis but only gets it spontaneously from his daughter Ellie (played by Sadie Sink).  Ellie is an angry teenager, performing suboptimally in school and she directs much anger at Charlie for abandoning her at 8 years of age when he left for the relationship with Alan.   Charlie actively seeks a relationship with her and at one point promises her a large sum of money just to spend more time with him, even though the time he has left is measured in days. He repeatedly apologized for his “bad decisions” in the past and emphasizes that he wants to try to make things right.  He would go as far as helping her write essays that might allow her to pass to the next grade in high school.

Two other characters are introduced over the course of the film.  Thomas (played by Ty Simpkins) shows up at Charlie’s door one day as a Christian missionary. He presents himself as a person intent on saving Charlie through God and Christianity.  He comes into dialogues with both Liz and Ellie.  Liz pointedly tells him to stay away from Charlie - that there are people who do not need to be saved.  She also points out the significant flaws in the local church that Thomas is affiliated with. Her father is the pastor of that church and Alan was her brother. Her father tried to arrange a marriage for Alan and described his suicide as a tragic accident. In his conversation with Ellie, Thomas discloses enough details of his life and why he might be estranged from his parents that Ellie is able to track them down. That eventually leads to reconciliation.

Charlie’s ex-wife Mary (played by Samantha Morton) appears toward the end of the film. There is a detailed discussion of the mistakes that were made and Mary’s chance meeting of Alan in a WalMart parking lot.  Even though there is a lot of tension, there is still an obvious level of caring between Charlie and Mary. Mary discusses Charlie’s unflagging optimism as one of his attributes that she misses. At some point it becomes obvious that the large sum of money that Charlie intends to give to Ellie may have come at a cost to his own health.  He has no health insurance and Liz points out what additional services he could have received.  Charlie refuses medical care and emergency services based on the cost, although that refusal is also consistent with his self-destructive path. He hears Liz describe the stress that he is putting her through but is unfazed.

Throughout the film, an essay about Moby Dick is referred to. The basic message of the essay is that the author can deny aspects of his own life and introspection about it – by focusing on killing whales. We eventually learn that this essay was written by Ellie when she was in the 5^th grade.  Charlie asks people to read him the essay when he is in a medical crisis with chest pain, shortness of breath, and diaphoresis.  He finds it comforting.  He also retypes the essay and gives it to her for school and she becomes enraged when she finds out. Charlie emphasizes that he only meant to show her that he appreciated her intelligence and creativity.

At a psychological level, Charlie is dependent and self-effacing. His motivation appears to be trying to correct past mistakes, especially abandoning Ellie, even though that was a complicated process that he was only partially responsible for. His reaction in these problematic scenarios is to accept the blame and go far beyond that to see himself as a disgusting person and ultimately a physically disgusting person (his characterization) that he produced by excessive eating.   

Several reviewers commented on the empathy in the film, but I really did not see any. Nobody seems interested in what happened to Charlie and how he got into this predicament – only that he is in it. They are attached to Charlie for various reasons but also out of their own self-interest.  As in real life, a lot of emotion happens in those settings as people are frustrated with Charlie when he does not accept their advice.

A relevant psychiatric dimension is the issue of involuntary treatment. In these last days of his life we see that Charlie has very high blood pressure, congestive heart failure, and possible angina that necessitate emergency care. Liz confirms that she has discussed his situation with an emergency medicine physician who concurs with her opinion.  Charlie even Googles his numerical blood pressure to confirm that it is an emergency. And through the film, he says he will not be treated and Liz agrees that she will not force the issue. But suppose that she wanted to.  What might happen in this situation?  Charlie could be transported to the ED, treated, and agree with admission for stabilization. He has no apparent psychiatric diagnosis, but it does not take too much imagination to see how any extended dialogue would get into the area of self-care and self-destruction to the point that the attending physician would consider an emergency hold. It is not uncommon to see people who have secluded themselves and not taken care of themselves admitted to inpatient psychiatric units with as many medical problems as Charlie. Suicide by food or lack of self-care is less dramatic than other methods but it can produce the same result.

Would Charlie be seen as depressed?  Probably – but is that the real problem? Moral injury seems to be a more proximate cause superimposed on a man who accepts all of the bad things happening in his life as his fault and reacts according. It allows him a veneer of optimism, while never having to confront the realty that human relationships are more complicated than that.  

Psychiatric speculation aside, this is a complex film that you must see.  The writing and acting is excellent.  The interpersonal drama has unique dynamics and is first rate.  I hope to see all these actors in other projects. It is a well thought out story line – right down to Charlie’s Zoom exit from his creative writing class. And importantly there is a clear message that there are all kinds of people out there struggling through life as best as they can every day. Those struggles may prove resistant to the insights and best advice from others.   

 

George Dawson, MD, DFAPA

I Have Hit A Wall

 I am currently working on two complex posts that will require a lot of research and graphics work but hopefully will be worth it at the end. I thought I would include a few comments about this here basically to document the progress and to see if anyone has already done the more detailed neuroscience post.  I also plan on taking a break by posting on a topic that I can more easily cover about – subclinical hypothyroidism.  That will hopefully appear in the next few days. There is a long history of endocrinology interfacing with psychiatry and as a research fellow in that field I am very aware of the associated concepts.

The complex posts are the neuroscience of a central autonomic network (CAN) and the borderline personality disorder concept. I am very interested in the CAN because of the issue of cardiac anxiety. In other words – can the heart itself be a source of anxiety and if that is the case should it be addressed differently?  And what are the implications for nosology?  The current DSM approach is agnostic when it comes to potential mechanisms of anxiety, but should it be? Considering the wide variety of medical approaches for anxiety including a few that are cardioselective – it would be useful to know if the anxiety originates in the brain or somewhere else and if that implies a different type of treatment.

The borderline personality disorder concept has always been controversial – but various psychiatrists and researchers also have a history of addressing the controversies and providing solutions for patients.  Most importantly those techniques have demonstrated efficacy for reducing suicidal ideation and self-injurious behaviors. Despite those advances an editorial in a recent British journal called for the abandonment of that diagnostic class and substituting an older diagnosis. Much of the justification for replacing the diagnosis seems to suggest that it is a pejorative label.  Having worked in a multitude of medical settings I can attest to the fact that pejoratives exist everywhere in medicine and it has very little to do with diagnostic criteria. It is largely related to countertransference issues by health care workers who are unaware of that concept and who are psychologically unable to maintain a neutral stance in emotionally taxing situations with patients. Changing a diagnosis is unlikely to change that predicament. I could generate a long list of what I have heard patients referred to – but is counterproductive and does not address the issue. I am not suggesting that every health care worker needs training in countertransference management.  Maintaining a professional stance can occur with appropriate coaching, education, and supervision.  As an example, I was asked to consult during a grand rounds on this topic presented by Emergency Medicine and comment on physician reactions in common situations.    

The basic problem with the CAN concept is not the basic structures involved but the initial signals and connectivity.  As an example, I am looking at my diagram of the subfornical organ and note there are 10 major efferent connections and 6 major afferent connections with some overlap.  The subfornical organ is one very small component of the CAN.  Not sure about my ability to diagram that complexity but I am going to give it a try.

I am also hoping this comment about hitting this wall provides me with some insights on how to approach this work. My only full-time job these days is blogging. After doing several presentations in the past year – I know I am much more enthusiastic about what I am researching and presenting than anybody who attends those presentations. I am also aware of the biases in society against old people and retired people. But I can’t let any of that get to me. I will stop when it is obvious that I have nothing left to contribute or I am stopped by a health problem.   

When you are a blogger – it seems like it is always feast or famine.  I have been very productive and posted what I think are excellent posts that nobody reads.  At other times and seemingly out of the blue there are bursts of reader activity that are hard to decipher with the available tools on blogger.  A friend of mine read through a few of my posts and said: “That is a lot of work.”  I appreciated that comment because it captured the reality of many posts and the implicit “for nothing.”  I still think there is an undercurrent of thinking that all bloggers or influencers get paid for what they post.  I have never been reimbursed for what you see written here and all the permissions that I have acquired over the years specifies the non-profit aspect. 

Finally – if you do read what I post here I appreciate it. Take the time to let me know if you want to see any psychiatry or medicine specific topic and I will do my best to write about it. If you look back over the years of posts – several firsts have been posted here that are not seen anywhere else – both in psychiatry and medicine in general. I see that as validation of some of my approaches.

In the meantime – stay tuned!

 

George Dawson, MD, DFAPA

 

 

Graphics Credit:

Atrribution:

I, Xauxa, CC BY-SA 3.0 <http://creativecommons.org/licenses/by-sa/3.0/>, via Wikimedia Commons

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