Thursday, August 26, 2021

Drapetomania - The Lack of Relevance To Psychiatry

 


I will address this issue one final time. I have written about it in the pages of this blog in past. Drapetomania was a pseudo diagnosis coined by Southern physician named Samuel A. Cartwright. He wrote the following in 1851:

“DRAPETOMANIA, OR THE DISEASE CAUSING NEGROES TO RUN AWAY.
It is unknown to our medical authorities, although its diagnostic symptom, the absconding from service, is well known to our planters and overseers...
In noticing a disease not heretofore classed among the long list of maladies that man is subject to, it was necessary to have a new term to express it. The cause in the most of cases, that induces the negro to run away from service, is as much a disease of the mind as any other species of mental alienation, and much more curable, as a general rule. With the advantages of proper medical advice, strictly followed, this troublesome practice that many negroes have of running away, can be almost entirely prevented, although the slaves be located on the borders of a free state, within a stone's throw of the abolitionists.” 

Characterizing running away from slavery as a disease and physical punishment as a treatment was certainly a radical concept even in the Southern states before the American Civil War. In subsequent paragraphs Cartwright invokes divine providence to explain why white masters are destined to remain in a superior role to slaves.  He was concerned about “two classes of person who were apt to lose their negroes – the overly permissive defined as “treating them as equals” and the cruel owners who denied slaves the ordinary necessities of life.  His solution was to treat them well enough, but not allow many freedoms, and physically punish them into a submissive state “for their own good.”  Since Cartwright wrote these paragraphs the common interpretation is that his disease characterization of a rational act is a prototypical misapplication of the disease concept.

Not much has been written about criticism at the time. Writing in the Buffalo Medical Journal Samuel Hunt provided a satirical editorial on the original paper (2):

“Our purpose in this formal introduction, is to give due importance to an article recently published in its pages by Dr. Samuel Cartwright, of New Orleans. Characterized by the same cautious induction and logical accuracy whichever attended the literary efforts of that gentleman, it deserves careful consideration of the medical philosopher, the anatomical statesman, and the benighted Saratoga convention.

Those of our readers who are in the habit of referring to Cullen’s Nosology for the definition of diseases, will find no mention there of Drapetomania. The ignorance of the ancients was surprising, and we need but refer to Drapetomania as an evidence of this progressive spirit of the age in which we live.

Dr. Cartwright has conferred this name, Drapetomania, upon a disease peculiar to the south, and which is, we believe entirely confined to that section, and only manifested at the north in certain analogous if not identical forms, which we shall have occasion to mention when we have given our readers time for the perusal the following extract from Dr. Cartwright’s able article:”

After additional sarcasm following the extract, the author goes on to close his editorial by describing a disease he calls Effugium discipulorum or a tendency of school boys to leave school and spend time in the fields and orchards of rural districts. He suggests that the same solution – whipping “have been sanctioned by ages of experience in Effugium discipulorum; thus confirming the allied nature of the 2 diseases and the correctness of Dr. C’s hypothesis.” Hunt’s satirical editorial of 1855 and additional sources describing how the paper was mocked in the northern states is an indication of how serious this “diagnosis” was taken by some physicians at the time.

Historian Christopher D. E. Willoughby (3) described a much more nuanced environment and the multiple roles that Cartwright played. He was apparently widely published on a number of medical topics and there was widespread interest in the medical community about racial differences in medicine. Cartwright portrayed himself as an expert in this area, but due to his reputation he generally received deferential treatment – even when other physicians disagreed with him.  The medical emphasis at the time was on anatomy and in terms of disease theory there was a doctrine of specificity outlining the few factors relevant to how a disease could be treated. One of those factors was race. A physician could be regarded as a quack if one of these factors was disregarded – reinforcing the role of racial medicine. Despite Cartwright’s medical and political role, Willoughby describes his drapetomania as being so far outside of the medical norms at the time that drapetomania was not adopted as a diagnosis by many physicians and it was never a psychiatric diagnosis for the obvious reason that psychiatry and its diagnostic systems did not exist.

.The sampling of how often the term was used over the intervening decades both independently and relative to actual psychiatric diagnoses is indicated in the following Google NGRAMS.  To read about the graphing procedure consult this source (4). (Click to enlarge)




It seems fairly obvious that there was a flurry of references around the time of Cartwright’s article and then a very long flat period until Szasz resuscitated it in the 1970s (5) and it was picked up by the anti-psychiatry crowd subsequent to that.  Given the Google NGRAMS approach, relative to standard psychiatric diagnoses the interest in this pseudo diagnosis was practically nil.

A critical question is how a theory largely ignored at the time, now has more references than in the past?  A lot of that may have to do with a reinterpretation of his image. The description of him as a respected surgeon who trained with Benjamin Rush at Pennsylvania Hospital was apparently due to mistakes in an early biographical history (3) and persist today in Wikipedia and many other places.  Further reading suggests that he was in medical school as a teenager, dropped out to fight in the War of 1812 where he sustained injuries and then went back to complete his medical training. Looking at that timeline does it seem plausible? (click to enlarge)


Cartwright was born in 1793. In the years 1808-1813 he would have been 15-20 years old. Benjamin Rush died in April of 1813 and had been ill since the previous November. His biographer Stephen Fried (6) described Rush writing and active doing hospital rounds during this time period but for the first time starting to miss those rounds. It seems unlikely that even in the 19th century that anyone in their late teens would have been a military veteran and in medical school between the ages of 15-19. Willoughby (3) confirmed that there was no evidence that Cartwright matriculated at Penn or that he apprenticed with Rush. There are a multitude of sites on the Internet and in papers that state otherwise. Contrary to these many references there was no connection between Cartwright or Rush and the University of Pennsylvania Medical School. He did graduate from Transylvania Medical School (Lexington, KY) in 1823.

What about the purported connection between psychiatry and Cartwright and his invented diagnosis? Per the timeline above psychiatry had not yet been invented. There was an organization of asylum superintendents at the time but they had no formal diagnostic system.  The Association of Medical Superintendents of American Institutions for the Insane (AMSAII) was founded in 1844 and it had a total of 13 members - none of them were described as psychiatrists or alienists.  Despite the fact that racism and proslavery attitudes were widespread,  none of them used the term drapetomania or admitted asylum patients on that basis. In fact, only one asylum accepted slaves with mental illnesses at that time.  

The American Medico-Psychological Association was established in 1892 and at that time the number of alienists versus psychiatrists was not known.  In fact, it wasn’t until a meeting of the Alienists and Neurologists of America in 1917 (7) that anyone suggested specific training was necessary to treat asylum patients.  In those proceedings there are three times as many references to alienists than there are to psychiatrists, despite Reil’s first use of the term in 1816.  No mention at all of drapetomania but an interesting section on the importance of social diagnosis and social work.  The main diagnostic focus was on alcoholism, catatonia, epilepsy, syphilis, dementia praecox, various forms of chronic illness, and intellectual disability described as “feeble mindedness”.  None of the alienists or neurologists seem remotely concerned about drapetomania.  This is the only reference to race in that 228-page document:

Preservation of self and of the race are directly dependent upon gratification of the appetites and this fact necessitates reaction of man to his environment and appropriation of those things which serve to fulfill his desires.”

It was included in a section on “Criteria of Defective Mental Development”.

On the timeline, the initial forms of psychiatric diagnostic manuals appeared in 1918 and 1952. Neither contained any reference to drapetomania and most of the diagnoses proposed are recognized as being similar or precursors to current diagnoses. One of the often-used tactics in criticizing psychiatry today has to do with the diagnostic manual and what it means.  Contrary to the rhetoric, alienists and psychiatrists involved in asylum care were often criticized for the lack of science in those settings most notably by the neurologist Weir-Mitchell (8):

“I shall frankly have to reproach many of those who still bear the absurd label of ‘medical superintendents'. Where are your annual reports of scientific study of the psychology and pathology of your patients? We commonly get as your contributions to science, odd little statements, reports of a case or two, a few useless pages of isolated post mortem records and these are sandwiched among incomprehensible and farm balance sheets”.  He went on to state that neurologists believed asylum care was care of “last resort”.

From the start psychiatric diagnostic manuals had the dual role of diagnostic description and data collection in asylums, specialty hospitals, specific populations, and for research purposes. Contrary to modern antipsychiatry philosophy there was no goal to increase diagnoses or the number of people with a diagnosis and no goal of social control through diagnosis.

I have established that Cartwright had no connection to Benjamin Rush of the University of Pennsylvania medical school. I have also established that drapetomania was certainly not accepted as a diagnosis and was probably widely derided in some areas.  It was essentially a product of the racist south, inadequate diagnostic theory and medical racism, had medical and political implications, and was written by a physician who owned 14 slaves and had a personal interest maintaining that practice.  I have also established that it has nothing to do with the field of psychiatry or its intellectual roots. It is only through massive misinformation that these false ideas persist. That misinformation landscape if so large at this point that it is not likely to ever be corrected. I certainly doubt that this blog will have much of an effect against what is now decades of drapetomania misinformation.  Many of the people spreading that misinformation are doing it in bad faith and by definition are not interested in correcting it.  There are also many (presumably) good faith errors such as recent statements from within organized psychiatry and in texts. A psychology colleague posted that every undergraduate Abnormal Psychology text uses drapetomania as an example of coercive psychiatry. Hopefully the good faith errors will correct themselves.  

The modest goal of this post is to hope that I can keep all of this misinformation out of the psychiatric literature.  That will be no small task. Szasz is already published despite the fact that he has been widely discredited. Even last month I was reading the American Journal of Psychiatry (9) and came across this statement:

Over 60 years after the ratification of the US Constitution, physician Samuel Cartwright played a prominent role in the rise of racism in psychiatry.  His descriptions and characterizations of mental health conditions in enslaved Africans, particularly drapetomania which he described as the illness of enslaved people wanting to run away and escape captivity, and dysaethesia aethopica, a disease of ‘rascality’, were the beginning justifications of pathologizing normal behavioral responses to trauma and oppression.”

Based on everything I have established this is an inaccurate statement. Cartwright was not a psychiatrist or even an alienist. He was not trained in researching or diagnosis any mental health conditions and essentially made these up. His isolated racist ideology has nothing to do with the subsequent development of psychiatry or the way psychiatry is practiced today. Cartwright and drapetomania have become a convenient meme with the imitators using it as an indictment of psychiatry or the psychiatric diagnostic system – even though it is unrelated to both.  The latest application has been the use of this meme by psychiatrists to acknowledge systematic racism within the field as a basis for future correction. I have no problem with acknowledging that racism in psychiatry and society exists – but let’s make that acknowledgment on a realistic basis not an unconnected anecdote.

I expect a fair amount of opposition to this post. I base that on a reaction I got in a psychiatry listserv when I suggested that professional organizations should suggest the Rosenhan paper be retracted. Although I got several very supportive replies and replies from people who were shocked about the facts, there was also a very vocal contingent proclaiming they want social justice. Social justice cannot be predicated on a misinformation, even if that misinformation seems consistent with your overall message.  And there is a much better way.  That better way was in this weeks New England Journal of Medicine (10) in an article highlighting the work of W.E.B. Dubois and his colleagues who accomplished what can only be described as landmark work in the area of structural racism. In it DuBois and colleagues concluded that the excess mortality from tuberculosis in the black community was a product of racial disparities secondary to social forces. The report was published in 1899.  DuBois also successfully countered the theory of an insurance company actuary who suggested that black people were “ill adapted to freedom but also doomed to imminent extinction because of their biological differences from white people.” (note the parallels with drapetomania). Dubois successfully refuted these claims and showed that heredity could explain only a small part of differential mortality between groups and that social inequity accounted for most differences. The work of these social scientists and theorists is a solid place to start.

The solid scientific ground that we are on today is that we know race is a non-specific factor and that biologically all of mankind comes from the same place.  We are much more biologically similar than different. Discrimination and the resulting outcome disparities based on racism are the real problems to be addressed and there has been a scientific basis for that since 1899.    

 

George Dawson, MD, DFAPA

 

References:

1:  Cartwright SA.  Diseases and Peculiarities of the Negro Race.  De Bow's Review. Southern and Western States. Volume XI, New Orleans, 1851  Link

2:  S. B. Hunt (1855). "Dr. Cartwright on "Drapetomania"". Buffalo Medical Journal. 10: 438–442. (full text). https://books.google.com/books?id=coBYAAAAMAAJ&pg=PA438#v=onepage&q&f=false

3:  Willoughby CDE.  Running Away from Drapetomania: Samuel A. Cartwright, Medicine, and Race in the Antebellum South. Journal of Southern History
The Southern Historical Association Volume 84, Number 3, August 2018 pp. 579-614; 10.1353/soh.2018.0164

4:  Younes N, Reips UD. Guideline for improving the reliability of Google Ngram studies: Evidence from religious terms. PLoS One. 2019 Mar 22;14(3):e0213554. doi: 10.1371/journal.pone.0213554. PMID: 30901329; PMCID: PMC6430395.

5: Szasz TS. The sane slave. An historical note on the use of medical diagnosis as justificatory rhetoric. Am J Psychother. 1971 Apr;25(2):228-39. doi: 10.1176/appi.psychotherapy.1971.25.2.228. PMID: 5553257.

6:  Fried S. Rush: Revolution, madness & the visionary doctor who became a founding father. Crown Publishing Group, a division of Random House LLC; New York, 2018.

7:  Alienists and Neurologists of America: Proceedings of Sixth Annual Meeting.  Chicago, IL  July 10-12, 1917.

8:  Shorter E.  A History of Psychiatry: from the era of the asylum to the age of Prozac.  John Wiley & Sons, Inc. New York, 1997: p.68

Weir-Mitchell’s criticism was delivered in 1894.

9: Shim RS. Dismantling Structural Racism in Psychiatry: A Path to Mental Health Equity. Am J Psychiatry. 2021 Jul;178(7):592-598. doi: 10.1176/appi.ajp.2021.21060558. PMID: 34270343

10:  White A, Thornton RLJ, Greene JA.  Remembering Past Lessons about Structural Racism — Recentering Black Theorists of Health and Society.  New England Journal of Medicine August 26, 2021 385(9):850. doi: 10.1056/NEJMms2035550

11:  Callender JH.  History and Work of the Association of Medical Superintendents of American Institutions For The Insane - President's Address.  Am J Insanity. July 1883: p. 1-32.

In this reference, the Association President reviews the first 40 years of progress and points out that 13 members started in 1844 but by 1880 there were 115 members representing 130 public and private institutions in the US or Canada and a total of 41,000 patients.  In this same document the President refers to the distinguished members of the organization as alienists rather than psychiatrists. Gonaver (see below) refers to the physicians of the AMSII as "asylum doctors" or "psychopathists" but also points out that many had no specialized training at all in the treatment of the mentally ill.


Supplementary 1:

This reference was posted to me on Twitter.  In it the author points out that the term drapetomania was not a diagnosis in the only asylum that treated slaves during the time when there was peak interest in the term:

"Readers may be therefore surprised by the conspicuous absence of these so-called conditions in the only insane asylum in which  slaves were patients."

Gonaver W. The Peculiar Institution and the Making of Modern Psychiatry, 1840–1880. University of North Carolina Press, 2019.



Supplementary 2:

The nosology text by Cullen referenced in the satirical critique of Cartwright's work is available online through the National Library of Medicine.  The only references to mental disorders were mania, melancholia, and bulimia.  

Cullen W (1710-1790).  Synopsis and nosology: being an arrangement and definition of diseases. Hartford : Printed by Nathaniel Patten, MDCCXCII [1792]: 80 pages.  Link to NLM

Supplementary 3:
 
I got this book in the mail today and read it.  It is a 1918 edition "prepared for the Committee on Statistics by the American Medico-Psychological Association" - see timeline. The text is 40 pages long, contains 21 diagnoses in the classification system and was designed to facilitate data collection for statistical analysis. There was a detailed section on race and ethnicity that would not be included in any modern analysis.  Drapetomania was not listed anywhere in this volume.


Supplementary 4:

Precursor organizations to the American Psychiatric Association published a journal - The American Journal of Insanity that encompassed the period of time when drapetomania was proposed. In order to see if there was any recognition of drapetomania in the line of journals that the APA considers related to psychiatry I went back and looked at one 1850s decade of the American Journal of Insanity and then did a search on the APA web site validated against terms like sitomania discovered in that decade of material.

On the APA web site, the time span of journals is indicated below:

American Journal of Insanity vol. 1 no 1 (July 1844) to vol. 99 no. 6 (May 1943)
American Journal of Psychiatry vol. 100 no. 1 (July 1943) to current time.

There were no references to drapetomania in the interval 1851-1859.

The search engine was validated to discover relevant diagnoses in the American Journal of Insanity.

The search of APA journals yielded 19 references dating back to 1971.  The first two references from that year were both written by Thomas Szasz.  The references in general have to do with racism in medicine including a recent number of references, some book reports including one about ADHD that for some reason contains the word drapetomania. 

The exercise in this supplemental information confirms that drapetomania was never considered a diagnosis in what are considered the early journals of psychiatry.  In my reading of the American Journal of Insanity I also found much to support Weir-Mitchell's 1894 criticism of the field (see above and reference 8).

Supplementary 5:

I received the following book in the mail today after a Twitter colleague referenced it.  The author Wendy Gonaver is a historian who had access to a significant volume of records from the only asylum that treated and accepted slaves and free black persons as patients and employed slaves as caregivers.  So far I have read the 18 page introduction and the writing and rationale are excellent.  She introduces a level of insight and objectivity that is rarely seen in the content that she is covering. On page 6 and 7 she debunks the importance of drapetomania that occurred right in the middle of the years she is covering for this book (1840-1880). In commenting on the complete absence of Cartwright's invented diagnoses:

"For good reason, Cartwright's work has become synonymous with all that was horribly wrong with both slavery and spurious science.... but Cartwright's posthumous notoriety does not appear to match his reputation during his lifetime.  His fabrications were, at least for Southern doctors who considered themselves serious practitioners, more rhetorical proslavery provocation than legitimate diagnoses." (p. 6-7).

She points out that Cartwright was not a "mental health specialist", never attended a meeting of The Association of Medical Superintendents of American Institutions for the Insane the only professional organization at the time, his work was never discussed at those meetings, and there were no records to suggest that slaves were admitted for running a way or that they were whipped.  There is also no mention of a connection to Benjamin Rush - another frequent error when Cartwright is discussed.

At the same time Gonaver points out that previous historical documents ignored race as a dimension for analysis and illustrates some of her insights in that area in the introduction.  I look forward to completing the book. 




A brief synopsis of the book follows:

After some consideration, I elected to post a synopsis of the book rather than each chapter due to the length of that document. The book is based on archives of the Eastern Lunatic Asylum (ELA) as reviewed by the author historian Wendy Gonaver. The descriptions of the state of the asylum, administration, staff including the enslaved staff, and the patient population role based on detailed notes by the asylum superintendent during the time interval of interest (1840-1880). Most of the material consisted of records written by John Galt, the superintendent. He was appointed age 22 and 1841 after studying at the University of Pennsylvania. He remained the superintendent until his death by suicide on May 18, 1862. Although the author refers to her book as a study of the “broader ideological underpinnings of early psychiatry” - the asylum doctors were clearly not psychiatrists. They are typically referred to as “asylum doctor” or “psychopathist”.  He was a member of the Association of Medical Superintendents of American Institutions for the Insane (AMAAII). This association was founded in 1844 and at that time it had 13 members. The only real connection to psychiatry is that the American Psychiatric Association uses this date to claim that psychiatry was the first medical specialty. That is a questionable claim on multiple levels.

The ELA itself was housed in an inadequate physical plant even in the pre-Civil War era. Sanitation was clearly a problem with inadequate drainage and sewerage systems. Potable water was also problem. There were a large number of fires on the campus for heating purposes until central heat could be installed. Nutrition was also a problem. Although the patients got about a pound of meat 5 days a week and fish 2 days a week several patients were diagnosed with scurvy. That led to an emphasis on expanded gardening of fruits and vegetables. Children of staff living on campus were not served regular meals but had to subsist on scraps.

One obvious conclusion is that there is much material in this book that could be used to blame psychiatry in much the same way that drapetomania has been used. But there are many qualifiers. Racism both overt and covert were clearly present in both the northern and southern states. Even though much of the events described in this book occurred 30 – 70 years after Benjamin Rush’s death there were no true abolitionists, not even reformer Dorthea Dix.  John Galt supported his enslaved staff in many cases humanistically but from a pragmatic rather than a moral perspective. He clearly believed that blacks were socially and intellectually inferior, but he realized that his institution could not run without enslaved blacks.  That led him to defend the quality of care provided by the enslaved staff at his institution. Racial stereotypes cut across the dimensions of religion, gender, and culture with African Americans receiving the harshest treatment and the greater work load. When John Galt died and the Civil War ended, the integrated ELA also ended and black patients were transferred to a segregated institution where their care was noticeably worse.  During a transition period, multiple military physicians with no training in asylum care were appointed to run the ELA.

Politics factored prominently in the workings of the ELA and whether Galt received any recognition for his work of ideas.  Shortly after his arrival, a conflict developed with the asylum board when they removed his hiring ability and blamed him for the resulting problems. He was also resented by AMAII colleagues over his advocacy for integrated asylums and eventually an outpatient community-based model. Despite praise for innovation at their meetings he was never credited for his ideas or his death mentioned in one of their meetings.

The author is a critical presence in this book. In places, she is clearly suggesting that stressors, abuse, domestic violence, war, and other forms of trauma may be the most important factors in why someone, but particularly white, black, and enslaved black women ended up in the ELA. She acknowledges that there may be a role for severe post-partum states. As I read though these case reports, I had questions about the degree of detail available as well as the primitive to non-existent diagnostic system. If all of the details of stressful events were there – could they really not be considered given the primitive state of medicine that was being used?  The only treatment being supplied was basically moral therapy and environmental containment to reduce the risk of aggression, suicide, and starvation.  There were no trauma or stress based therapies available in the mid-19th century. If there were it would take a much larger professional staff to administer them.

All things considered, the logical conclusion is that the ELA, like most institutions was not able to rise above the prejudices of the population where it was located. The practices described in the book are common overt and implicit racist themes – even today. Covert segregation still exists even though school segregation ended in 1954. In keeping with the timeline of this book, the Civil Rights Act of 1875 was supposed to have ended racial discrimination but the Supreme Court overturned it in 1883 saying that individuals and private business could discriminate on the basis of race.  

The Peculiar Institution is a very scholarly work. It is well written and I encourage anyone with an interest in the history of this time or discrimination based on race or gender to read it.  My only other concern is with the extended title – The Making of Modern Psychiatry.  I would submit that it really contains very little to do with modern psychiatry – and like Cartwright’s drapetomania diagnosis is more the product of racism, politics, and an inadequate system of care. 


Supplementary 6:

The state of Virginia lists Eastern State Hospital as the first mental hospital in the United States dating back to October 12, 1773 and states that at one point it was called the Eastern Lunatic Asylum.  There is some history available on this Virginia State web site including commentary on Dr. Galt.


Supplementary 7:

The journal Alienist and Neurologist: a quarterly journal of scientific, clinical and forensic psychiatry and neurology was published between 1880 and 1920 when publication ceased.

Full text of this journal is available via the HathiTrust web site

Supplementary 8:

Drapetomania errors on the Internet - needless to say there are many.  I thought I would catalogue them but do not have the time. Unless the use is restricted to Cartwright and not applied to psychiatry it is probably safe to say it is being used rhetorically. 




Tuesday, August 17, 2021

Beauty Contest or Cynical Marketing Scheme?

 



Beauty Contest or Cynical Marketing Plot?

Well this is the United States so it is a safe bet that the answer will be “cynical marketing plot”, but even then the beauty contest may not be an independent variable.  I just listened to a story on public radio today about how government contractors in Afghanistan basically had blank checks for the services they provided to American troops. We live in a land where the government basically stacks the deck in favor of corporations and there is no clearer example than the healthcare industry.

Today I received a letter in the mail that said

“Dear Dr. Dawson - we are pleased to include you among the Top Doctors to be featured as a Top Neurologist representing Circle Pines, MN.  We will be featuring you in our 2021 Top Doctor list which will appear both online in our nationally syndicated publications. Your expertise in Neurology and dedication to upholding the highest standards of patient care in the diagnosis and treatment of neurological disorders and diseases is something to be recognized. This four-color wall plaque is a beautiful addition to your wall of achievements. Signed, the Selection Committee”.

I was very skeptical of this letter from the outset for obvious reasons.  First, I am not a neurologist. Second, I do not live or work in Circle Pines, MN.  I considered reasons for the letter the most obvious one that it was simply an error. Sarcasm came to mind as I reflected on the many people over the years who told me I was too preoccupied with either neurology or medicine for a psychiatrist.  Was this a sarcastic joke based on that criticism?  Finally, I have encountered some people who think it is hilarious that you are assigned a job title in error. Was this an attempt to do that?  Finally - the marketing aspects.  I had received many solicitations to get listed in various Who's Who publications.  This was probably the medical version.  I have never been compelled to get a copy of Who's Who to find out who the prominent people are.  They are usually obvious - at least the ones that I am interested in.

I don’t know exactly when the “Top Doctors” lists started to appear. The past 15 years - I have received a mailing encouraging me to nominate certain doctors for this award. Lists are compiled by specialty and they don’t seem to change much every year. I glance at the list from time to time and agree with about 20% of the rankings. But in their defense, how should a “Top Doctor” be ranked? When I am personally looking for a “Top Doctor” for my own medical care or the care of my wife I am interested in what their results are. That applies to both medical and surgical care. That data is extremely hard if not impossible to find. Do the physicians doing the voting know these details? In some cases they might. I depend on my primary care physician and his experience with surgical referrals and the results that he sees from those referrals. In the case of nonsurgical care my speculation is that those results are more nebulous. In that case do the rankings have anything at all to do with outcomes or quality of care?

It reminds me of the type of rankings I got every year when I was an employee for a managed-care company. They could fluctuate 180 degrees from one year to the next because they were totally subjective.  One year I was ranked number one in documentation and coding according to subjective chart audits. The next year I was dead last even though nothing had changed in the interim. We also had an anonymous “360° evaluation” where other staff were encouraged to critique us and say just about anything they wanted whether it was relevant to work quality or not. The entire exercise lacked accountability and was demoralizing.  In my annual reviews I started to refer to it as “the beauty contest” reflecting its subjectivity and fickleness. My boss thought that I was joking - but I was not.

These political subjective ratings have a goal to elevate organizations that are run by business administrators while maintaining leverage over the physicians who work in them. There is no clearer example than driving through Anytown in the USA and noticing that they all have a top ranked hospital or medical clinic. There just are not that many top ranked hospitals and medical clinics in the country.   The “Top Doctors” list may be another one of these trends. Some of these lists tend to have many specialists from same clinic.

The beauty contest concept brings to mind Atul Gawande’s essay The Bell Curve from 2004.  He develops the premise that there is very little objective measurement of physician outcomes and even less disclosure. With that data it would be possible to construct a bell-shaped curve and find out where physicians are plotted against their peers. This would be an ideal route to find the Top Doctors list but he is more focused on what happens if you find out you are just average. In any statistical compilations people are bound to be average and even below average, but Gawande points out that settling for average is the problem and he even rolls in the idea of the beauty contest:

“And in certain matters - looks, money, tennis - we would do well to accept this.  But in your surgeon, your child’s pediatrician, your police department, your local high school? When the stakes are our lives and the lives of our children, we expect averageness to be resisted.”

Even though that essay was from 2004, the actual measurement of doctors remains elusive except for a very few instances. Gawande points out some of the reasons including what to measure, who is doing the measurement, what is all means, and what the implications are. He does not comment on the major extraneous factors that may shift the curve. In the last 30 years, the single largest factor is the business management of healthcare and the move away from substance – in particular quality – to advertising and fluff. There is probably no better example than my Top Doctors letter.

I want to be clear that the letter I got was all about signing up for a meaningless plaque to recognize me as the wrong doctor from the wrong specialty in order to get money. Are there other  doctors out there going along with this? Are there doctors who are purchasing meaningless plaques and putting their names on meaningless lists to enhance their resume? That is an investigation that I don’t have time for. This post is all about getting the message out that rankings and proclamations that doctors, hospitals, and clinics are “top rated” is not necessarily something you can hang your hat on.

Be very skeptical of ranking systems especially ones that are self-proclaimed - and try to get reliable information on what counts. With physicians that would include their outcomes, their thoroughness, and the relationship they are able to establish with their patients.  Gawande’s essay points out that relationship may not always be comfortable

Don’t get pulled into a beauty contest…..even though in today’s healthcare landscape they seem unavoidable.

 

George Dawson, MD, DFAPA

 

 

References:

Atul Gawande.  The Bell Curve.  The New Yorker.  November 28, 2004

Graphics Credit: 

Bathing Beauty Contest 1920.  National Photo Company Collection, Public domain, via Wikimedia Commons:  

https://upload.wikimedia.org/wikipedia/commons/0/01/11_women_and_a_little_girl_lined_up_for_bathing_beauty_contest_LCCN2001706323.jpg





Sunday, July 11, 2021

Updated Medication Checklist for Psychiatrists

 


I decided to update the medication list that I posted here last February.  Not much has changed but I am using it for another couple of projects that I am working on. I am currently working on a detailed look at medications psychiatrists prescribe that may interact with medications used to treat atrial fibrillation (see previous post). I am also going to try to arrange the medications on this list according to the purported mechanisms of action.  The current available systems include the Neuroscience Based Nomenclature (NbN) and the Anatomical Therapeutic Chemical (ATC) Classification.  Both of these systems will involve many more categories and reformatting of the document.  I would like to retain the single page format for convenience.

Per the previous posts on this blog, I devised this sheet in order to get a more accurate idea about what my patients had taken in the past.  I found that they were able to recall many more previous treatments by reading through the list and that it was relatively efficient. I posted this list to Twitter to solicit recommendations and corrections and made some of those changes.  Several people suggested alphabetizing the lists, but I typically put the most recent medications at the top of the list and medications that made be no longer manufactured or more rarely prescribed at the bottom. There were some recommendations for medications that are available in other countries but not the US. I would be amenable to modifying the list for specific countries if someone could edit the current list and make sure it was corrected for the country that you are practicing in.  You could also just type up your own list.  You will also find several medications that have been discontinued either for safety or economic reasons. They are on the list because there are still relevant to the medication history of many patients.

I found that this list was also useful for research projects.  I was involved in a research project last year where there was some confusion about what psychiatric medications would be allowed in a study that looked at antidipsogenic medication. I showed my list to the Principle Investigator and other colleagues working on the project and we decided in a brief meeting the drugs that would be included or excluded in the protocol by just going through the document and checking them off. 

I wrote a more detailed post on this list last February with some disclaimers.  The same disclaimers apply. I don't make any guarantees that it is comprehensive or that you will find it useful. I think it does a fairly good job of illustrating the kinds of medications that psychiatrists prescribe, but that is always relative to the practice setting. During 22 years of inpatient practice, I was responsible for prescribing all of the medications that the patient was taking.  I had access to very good consultants, but had to do the initial treatment, medication reconciliation and adjustments as well as trying to address any new medical disorders. You certainly learn a lot of medicine and pharmacology in that setting, but on the other hand it is extremely time-consuming and with today's productivity demands - I would not recommend it. Nobody pays you for doing the job of two people, even though it is very efficient and patient-centered.  

The only major class of medication excluded from the table are acetylcholinesterase inhibitors ACHEIs) including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne).  These medications are used in the treatment of Alzheimer's Disease along with the NMDA receptor antagonist memantine (Namenda).  Psychiatrists prescribe these medications and the only reason they were not included in the table is space and the fact it would have required major formatting changes. 

Watch this space for further updates.  I will date and post links to new updates in the space below with the dates that the update occurred. I will also post the table looking at drug interactions with medications used to treat atrial fibrillation in the previous post.

George Dawson, MD, DFAPA


Link to Updates:

I have received a fair number of emails requesting this document from GDRIVE.  This link seems to work for me and it is publicly available. If it does not work for you email me and I will send you the most recent document.

Medication Checklist 07.11.2021 Link 

Medication Checklist 07.11.2021 Link  (Corrects valproate/divalproex section)

Medication Checklist 07.11.2021 Link  (Corrects misspelling of Caplyta)




Wednesday, July 7, 2021

An Outstanding Paper on Atrial Fibrillation

 


I have been fascinated by atrial fibrillation since I was a third-year medical student. I was doing a Medicine rotation and examining a middle-aged man.  Listening to his heart sounds was the first time I heard the irregularly irregular heart rhythm characteristic of atrial fibrillation. It was such an outrageous and unexpected sound compared to what I was used to that I felt a little panicky. Why wasn’t this patient experiencing more symptoms and even more unexplainably – why doesn’t he sense that there is something wrong with his heart beat?  Since then, I have treated hundreds of patients with atrial fibrillation.  I ask them all if they can sense the irregular heart beat and in the people I see about half of them can.  Being a psychiatrist, diagnosing and treating atrial fibrillation is technically not my “job”.  But it is currently such a prevalent condition that a brief examination typically triggered by vital signs and noting a pulse irregularity followed by an electrocardiogram is all that is needed. Atrial fibrillation has considerable mortality and morbidity associated with the most feared complication of stroke. A good friend of mine developed renal failure from a combination of atrial fibrillation and atrial flutter and required ablation procedures to restore normal sinus rhythm.  Two relatives had strokes associated with atrial fibrillation resulting in disability and ultimately death. Both had atrial fibrillation for about 30 years.  One of them was 92 years old, using digoxin for rate control, and not on anticoagulants. The other was 92 years old, using diltiazem for rate control, and on warfarin at therapeutic doses. He had two strokes about 10 years apart on the warfarin and multiple episodes of nuisance bleeding or excessive bleeding from minor injuries due to anticoagulation that did not require medical attention.   Another friend had pulmonary complications from an antiarrhythmic drug that he was taking for a new onset of atrial fibrillation and died as a result of those complications. Sixteen years ago – I developed lone atrial fibrillation while speedskating and have been on antiarrhythmics since that time.

When you see all of those problems associated with a condition and have had it yourself, you tend to read more about it than the average person.  Reading about atrial fibrillation is generally a frustrating task. The evidence base for treating the condition seems to be in a state of flux. For years the research seemed to say that rate control and rhythm control led to equivalent outcomes. When life style measures were included, the rhythm control strategies seemed superior. Even the question of anticoagulation with novel oral anticoagulants of NOACs for stroke prevention based on a scoring system has been called into question recently.

That brings me to the topic of this blog post and that is the single best summary of information about atrial fibrillation that I have seen anywhere - at least for nonspecialists in that area.

The paper was written this year in the New England Journal of Medicine (1). It starts out with a case description of a 63-year-old man with a new onset of atrial fibrillation. The authors discuss the disease in detail and treatment recommendations consistent with their discussion. What I really like about this paper is that they are discussing phenotypes of atrial fibrillation and I do not see that happening very often in real clinical situations. The phenotypes they discuss are paroxysmal atrial fibrillation, persistent atrial fibrillation, and long-standing persistent atrial fibrillation.  They have an excellent figure in their paper that was unfortunately prohibitively expensive for me to try to post here, but the basic idea is that there are distinct anatomical and electrophysiological substrates for each of those phenotypes. In the paper the phenotypes are labeled as “clinical profiles”. His phenotypes have prognostic considerations since the authors make the point that there is a gradation in the likelihood of conversion to normal sinus rhythm and maintaining that rhythm with paroxysmal atrial fibrillation being the most likely to convert and maintain a normal sinus rhythm and long-standing persistent atrial fibrillation being the least likely to convert. Just knowing that much about atrial fibrillation is a significant advance compared with most of the clinical discussions that I hear.

The second feature in this paper that I really like is that atrial fibrillation is not necessarily a benign condition. For years the discussion has been controlling the rate or rhythm and in most cases they have been considered to be equivalent. Many clinicians have their first experience with atrial fibrillation like I had. They are doing a physical examination outpatient for another reason and they notice they are in atrial fibrillation. Depending on physiological factors that patients irregularly irregular heart rate may already be rate controlled. I have talked with many people over the years who knew that their heart rate was irregular because their spouse noticed it and they did not do anything about it for years. Atrial fibrillation is a risk factor for embolic strokes as well as dementia, death, and heart failure. Persistent tachycardia can cause cardiomyopathy and reduced cardiac output can lead to renal failure.  The authors suggest that a heart rate of 110 bpm or greater might lead to cardiomyopathy but they also suggest it can occur at a lower rate. This is an interesting observation because the most recent review in UpToDate on sinus tachycardia suggests it is generally a benign condition, however an irregular tachycardia because of reduced cardiac output is likely a different matter.

In addition, the patient can be symptomatic from reduce cardiac output with lightheadedness, dizziness, fatigue, decreased exercise tolerance, palpitations, hypertension, and an exacerbation of symptoms of underlying coronary artery disease. The lesson for psychiatrists is if you notice that a patient has atrial fibrillation it cannot be approached casually. Atrial fibrillation is associated with significant medical comorbidities such as underlying structural coronary disease, obesity, sleep apnea, hypertension, hyperlipidemia, and diabetes mellitus. If the patient has had limited contact with primary care physicians the comorbid conditions may have gone unnoticed. It makes sense to ask about additional symptoms in the review of systems as well as family history and whether that patient is seen primary care physician or cardiologist recently.  I would have no problem referring a patient with tachycardia, expected symptoms, or risk factors to an emergency department for acute stabilization if I could not get them seen in a primary care clinic.

The authors go into treatment of atrial fibrillation as basically a rate control strategy, a rhythm control strategy, and a strategy to address comorbid medical conditions.  They review rate control with beta-blockers and calcium channel blockers and prefer beta-blockers. They consider a number of antiarrhythmics and the risks and benefits of those medications.  They consider catheter ablation - either radiofrequency pulmonary vein isolation or cryoablation as being more effective for treating and preventing recurrent atrial fibrillation. The recurrence rates are relatively high even after the ablation procedures, so continued antiarrhythmic medications may be necessary.

Once a patient has stable treated atrial fibrillation, the main task for the psychiatrist is to make sure that any prescribed medications do not interfere with the cardiac medications at either the pharmacokinetic or pharmacodynamic level. QTc prolongation is a primary consideration since several of the agents used prolong the QTc interval or affect other cardiac conduction.  At the pharmacokinetic level there is the possible risk of decreased metabolism of beta-blockers and increasing bradycardia and hypotension. If I have any doubts all about medication combinations I am usually in touch with the patient’s cardiologist or primary care physician before making those changes. All of the patients I see with atrial fibrillation also have their blood pressure and pulse taken at every visit along with the description of symptoms and potential medication side effects. That means I never practice in an environment where I can't do that. I will also review how well their comorbid conditions are being treated particularly hypertension, sleep apnea, and diabetes mellitus. I will provide them with concrete advice on how to approach those problems and whether or not they need to be seeing their primary care physician sooner than scheduled.

This is also an opportunity to discuss any comorbid substance use problems. Alcohol is a definite precipitant of atrial fibrillation. I have had patients never experience another episode by stopping alcohol. I have also had patients report that they can tell when their alcohol level reaches a certain point because they will go into atrial fibrillation for several hours until that alcohol is metabolized. Stimulant medications are also a risk because they increase sympathetic tone, increase heart rate, increase blood pressure. All three of those changes can trigger an episode of atrial fibrillation.  Cannabis can have a fairly potent sympathomimetic effect by acutely lowering blood pressure leading to a reflex tachycardia. Atrial fibrillation has been reported as one of several cardiac arrhythmias associated with cannabis use (2). Interestingly, the authors of the NEJM article state that caffeine is not a precipitant. There are no qualifiers on that statement and I think it is based primarily on epidemiological evidence. Caffeine intake is always important to quantify because of its wide variability across the population and general reputation of being a benign compound. There are segments of the population that consume large quantities of caffeinated beverages every day and experience the expected side effects of anxiety (in some cases panic attacks), agitation, insomnia, and hyperadrenergic effects but they seem unaware that these symptoms are related to their caffeine consumption. Certainly consumption at that level can directly or indirectly precipitate an episode of atrial fibrillation.

That is my brief review of the NEJM article in atrial fibrillation. I encourage all psychiatrists to get a copy of this paper, read it, and keep it for reference. I am not suggesting that psychiatrists treat this condition.  I am suggesting that they recognize it - even if it has not been diagnosed and know what to do when that occurs. The reality is that in adult psychiatry no matter what your practice setting there will be a significant number of people with atrial fibrillation and other arrhythmias as well as all of the known comorbidities. You cannot treat those people unless you know about these conditions, the comorbidities, and how to avoid complications.

 George Dawson, MD, DFAPA

 

References:

1:  Michaud GF, Stevenson WG. Atrial Fibrillation. N Engl J Med. 2021 Jan 28;384(4):353-361. doi: 10.1056/NEJMcp2023658. PMID: 33503344.

2:  Richards JR, Blohm E, Toles KA, Jarman AF, Ely DF, Elder JW. The association of cannabis use and cardiac dysrhythmias: a systematic review. Clin Toxicol (Phila). 2020 Sep;58(9):861-869. doi: 10.1080/15563650.2020.1743847. Epub 2020 Apr 8. PMID: 32267189.


Supplementary:

Common and uncommon medications listed in this article used in atrial fibrillation for rate control, antiarrhythmic properties, and anticoagulation.  I added additional warnings and general type of medications that might require avoiding based on pharmacokinetic or pharmacodynamic considerations. Important to keep in mind that all medications vary in their ability to affect these mechanisms as well as therapeutic mechanisms. That includes significant differences between medications in the same class. That leads to qualifiers like "all possible mechanisms leading to complications or serious adverse effects may not be listed" (in this package insert or computerized drug interaction program). Almost every time I am seeing a patient on these medications - it requires a study of the medication combination, even if they are taking a psychiatric medication that appears to be working. Baseline cardiac symptoms related to the arrhythmia also need to be established as well as the patient's plan to obtain assistance if they worsen.

Additional qualifier (if it is not obvious). Psychiatrists prescribe beta blockers (metoprolol, propranolol, pindolol, etc). Psychiatrists can diagnose atrial fibrillation. Psychiatrists do not manage atrial fibrillation but need to know what to do acutely and how to avoid complications of the following medical therapies from drug interactions with psychiatric medications. Practically all of the antiarrhythmics in the following table are prescribed by Cardiologists and subsequently managed by primary care physicians although many patients continue to see Cardiologists in follow up. Like all areas of medicine the limits of technical expertise need to be recognized.  I worked with Cardiologists who became psychiatrists and they restricted their practice to medications prescribed by psychiatrists.  










Graphics Credit:

Bunch TJ, Cutler MJ. Is pulmonary vein isolation still the cornerstone in atrial fibrillation ablation? J Thorac Dis 2015;7(2):132-141. doi: 10.3978/j.issn.2072-1439.2014.12.46

Open Access per this Creative Commons License: https://creativecommons.org/licenses/by-nc-nd/4.0/     




Sunday, June 27, 2021

The Spiritual Journey From High School Football



About 2 years ago my wife said to me one morning “who is this guy who keeps texting me?” I looked at her phone and recognized the name immediately. He was the quarterback from my high school football team. More correctly it was the high school football team I was on when I was a sophomore in high school. I had the immediate association to his physical appearance and considerable athletic ability. To this day he probably was the most gifted high school athlete I had ever seen. He didn’t look like a high school player - more like a college player. He was also an excellent basketball player and sprinter on the track team. He was the fastest man over 100 yards in high school. Why was he suddenly texting my wife?

He was going to be inducted into the local athletic Hall of Fame. He was trying to organize a reunion of our 1966 undefeated high school football team. His plan was to get as many of us back there as possible - details to follow. There were 2 or 3 subsequent postponements of the reunion due to the pandemic. But yesterday on 6/26/2021 it finally happened. Twelve of the 22 players reunited for about 3 hours at a local bar. As far as I know three of my teammates are deceased and the remaining players could not be located or decided not come. The head coach was also in attendance. The assistant coach is deceased.  All of the attendees got baseball caps with their name and numbers embroidered on the back. The front of each cap simply said “Undefeated 1966 AHS Football”.

Unlike my high school reunion, I had the opportunity to say something to all my teammates. I remembered who they all were and details from our past. I know that many had significant problems in life including life-threatening health problems. I learned about their relatives who had similar problems. But most of all I learned about what that football season meant to the people who made it back to the meeting. I know that memories from over 50 years ago can get complicated and distorted. As we all sat around a table there was a collection of newspaper articles and photographs from 1966 to provide partial corroboration. There were some intense memories from the past that haunted some of the players. There was also active feedback from the coach about a few incidents where he realized that the plays he was calling were being ignored. My intention in writing this post is not to identify people with problems or criticize people, but to look at an event with obvious meaning as well as the meaning that may have been missed at the time.

Our quarterback started out with some self-disclosure of mistakes he had made during the championship season. Other players who were involved with those mistakes corroborated them immediately. Our center for example recalled a fumble on the opponents 1 yard line and the fact that it occurred on a silent count. For 5 decades our quarterback was thinking the fumble was his mistake, but our center let him know that he forgot the count. There were several other incidents involving typical football mistakes that people had been thinking about since 1966.  Resilience came up as an outcome of the coaches role in helping us overcome adversity.  

A significant injury was discussed. From the description it sounded like a traumatic brain injury, but back in those days any head injury with partial or significant loss of consciousness was referred to as a concussion. There was no grading system but persistent confusion or memory loss might eliminate a player from the game although that was certainly not guaranteed. More than one concussion led to a medical evaluation but again there was limited medical expertise in traumatic brain injuries. It led me to recall a lot of headaches from playing football. We would practice twice a day in hot weather hitting a blocking sled and doing full contact drills. There were days where the headaches just did not clear up.  I was also reminded of the only significant traumatic brain injury that I sustained when I ran into one of my teammates playing in a touch football league. In fact, I approached him at this reunion and joked that the last time he and I met - I was out of it for the next 24 hours. I had to explain that we were both defensive backs running full speed and I ran into a shoulder after diving for the ball. He did not recall the incident.

There was a strong underdog theme. At one point in the year, we did not have enough players to scrimmage so the coaches had to play defensive half backs. Many of the teams we played against had much larger players and significant depth.  That led me to recall our coaches quote to the press: “We are not big - but we’re slow”.  Our coach recalled that in some of the venues we were ridiculed for looking raggedy and not having many players. We were accused of running up the score against some teams to improve our overall ranking.  The coach found this humorous because there was no second team to put in.  At one point during the discussion, one of our receivers took over and talked about how he and one of his friends in the offensive and defensive line got psyched up for the game. He gave an inspiring and expletive filled speech about his love of football, how he liked physical contact, how he liked playing offense and defense. He presented it with such vigor that it seemed like he was ready to play - right then.

For some reason, I had forgotten how tough these guys were. We were almost all working class.  Half of us were from the East End and half from the West End of town. Some played with significant physical disabilities. It was the height of the Vietnam War and many would go into the Marines and the Army after graduation. Many would go on to play college football. I would just catch glimpses of their lives from time to time.  Everyone had a unique trajectory from that winning football season to where they were on June 26.  At one point a small group asked me what my trajectory was and I told them a variation of a story I have been telling for the past 10 years:

The only reason I ended up going to college was to play football, be a football coach, and teach physical education.  I had a football scholarship to a small college in the area, but within a few weeks, I developed a gangrenous appendix and was hospitalized for a week.  The coach came in and told me that the scholarship was mine even though I could not play anymore (I had a healing surgical scar in my side that was still healing after a drain was removed). I probably was headed to be a version of a hippy anyway. Another professor visited me and told me to forget about Phy Ed and football and concentrate on something else.  I had excellent chemistry and biology professors and knew that I wanted to be like them and know what they knew.  From there it was a change to biology and chemistry, the Peace Corps, a plant tissue culture lab and medical school.”

That’s the short version.  There are embellishments for comedic relief and more details if anybody wanted to hear it.  I leave out the heavy parts about being depressed to the point my grandfather showed up one day to encourage me to stay in college and not knowing what was wrong with me until I developed severe abdominal pain. I leave out the part about not taking a student deferment during the lottery for the draft.  A high lottery number rather than a conscious decision kept me from being drafted.  All part of the lack of a coherent plan. Nobody wants to hear about all of that. I never played college football.  The point is – I would never have stepped into that sequence of events culminating in medical school and psychiatric residency without that football scholarship. I never would have had that football scholarship without playing with this team and being coached by this coach. Some people will tell me that sequence of events would have happened anyway. That I would have made it happen through another channel. Whenever I mention being lucky on this trajectory, I encounter aphorisms like “Luck is just preparation meeting opportunity” and others.  But I really was not prepared to do anything at that point.

The only thing I was prepared to do in high school was play football. The teaching and guidance side was totally lacking. I can not recall a single piece of good advice that I received from a teacher or guidance counselor in those years. And the teaching was atrocious. You showed up, put in the time, did not create any problems and graduated from high school. The blue-collar ethos of education.  You did not have a plan until you got to the next stage. The modern-day stories of high pressure on high school kids to get into an Ivy League schools and parents going to extraordinary and in some cases illegal lengths to get them in - is lost on me. I am the poster child for getting into whatever college wants you and establishing goals after getting there.

Football was the initial pathway.  At the Reunion, the coach discussed some of his initiatives including the first strength training program at the school along with associated competitions. I remember summer training sessions including agility drills.  I excelled in agility drills and back and forth sprinting drills. In my senior year, I could equal or beat the fastest running back in the agility drill even though he would beat me by a mile in 100 meters. These summer sessions were something we all looked forward to and it was the only planned activity in my life for the 3 years of high school.  The Coach gave us a glimpse of what it took for him to implement these plans and all of the resistance he met along the way.  That resistance came in the form of administrators claiming that he was running afoul of certain regulations, personality conflicts, and suggesting that he should work the pre-season for free even though he was already undercompensated for the amount of work he was doing. Providing me with some structure to start to get my life together came at a considerable cost to the only guy who was doing it.

Several of my teammates provided additional stories about the immediate benefits of coaching. How to play against a much larger man with limited lateral movement.  How to make adjustments during the game, based on observations by coaches who were at ground level on the side lines, attending to the injured on the sidelines, and changing overall game logistics. High school coaching is a multi-tasking job and school districts get their money's worth from coaches.

One of the most important aspects of my life trajectory has been identifying with teachers along the way.  Most of that emphasis was in college at the conscious level. But did it occur in high school football?  I was never encouraged to play any sports by my father. I learned after his death that he was quite accomplished in baseball and softball in his early twenties. By the time I knew him well, he had been working a thankless job for twenty years. The only sports advice he ever gave me was: "Look - if you want to play sports be clear that you are playing it for you and not for me." He did live to see this football team and attended the end of season banquet prior to his death in 1967.  I never got the chance to completely understand his sports advice, but speculate that it was from having to fish every day during The Depression to supply food for his family of origin - whether he wanted to or not.  

Both of our coaches were young men, accomplished athletes, and had unique personas. I remember the head coach bench pressing a significant amount of weight even though he was a quarterback in college. For the rest of my family, sports were something you did into your early 20s and then you settled into a fairly sedentary lifestyle. Out of college and then again out of med school I embarked on a lifelong schedule of rigorous training for no reason other than being able to do it.  That continues to this day. Would I have logged all of this activity if I had not played high school football with this coach? Probably not. Was there a degree of unconscious identification with this coach?  Probably.

The developmental aspects of high school football are undeniable and the stage we were all at during the reunion was undeniably different from high school. High school male athletes are competitive either by choice or necessity. It was probably the most significant motivator. I can remember thinking about the difference between competing with myself and competing with others as I was running a long sprinting drill in the 90 degree heat that occasionally happens in northern Wisconsin. In that drill 5-10 players spread out across the field and run out to the 5 yard line and back and then the 10 yard line and back until they have reached the 50-yard line and back.  At some point during that drill you realize that competition is irrelevant because it really comes down to survival and in that sense you are competing against your own physical limitations.  That familiar mind set was with me for the next several decades of cycling and speed skating. With a single exception - I preferred to do both activities alone – just me and the rhythmic breathing and sweating of that familiar sprinting drill.

The competitive aspects of high school sports also play out in other ways. Clique formation, hazing, bullying, sarcastic comments, and various forms of acting out that are expected of teenagers who we now know don’t have fully developed brains for another 10 years. That was moderated to some extent by the shared suffering of football.  At the Reunion it was fairly clear that there were many accomplishments over the course of these lifetimes but also much suffering. We were all grateful to have survived so far and saddened by the loss of our teammates who did not.

55 years had passed and, in some ways, we were a better team.

 

George Dawson, MD, DFAPA


Postscript: 

If I am correct in my analysis (or not) - I am grateful to have had this experience in high school.  I am grateful for my teammates many of whom I consider to be friends but also the Coach and Assistant Coach who clearly did not get enough credit for what they did. I made the common mistake of also taking that coaching for granted until I realized that my entire career may have been based on it.


The commemorative cap:




Supplemental Qualifier:

I don't want to give anyone the impression that this is an endorsement for football or other contact sports.  Football is a collision sport and there is an expected morbidity associated with collisions. Chronic traumatic encephalopathy is one outcome that has received a lot of press. My speculation is that spinal problems also occur as the result of spinal compression and hyperextension movements that are harder to detect due to the high prevalence of spinal problems in the general population that does not play contact sports.  One of my teammates sustained a cervical spine fracture from football but it did not result in paralysis.  As a psychiatrist, I have seen a significant number of people with traumatic brain injuries and severe musculoskeletal injuries from collision sports.  The number of women with those injuries has increased as their exposure to these sports (soccer, lacrosse, ice hockey) has increased.  I have seen young men and woman in their early 20s with significant disabilities from these injuries. In some cases they have also had severe post-traumatic stress disorder (PTSD) from either the injury or the subsequent course of treatment. 


 


Sunday, June 20, 2021

How Physicians Think




One of the more interesting aspects of my career has been contemplating how physicians make decisions on both the diagnostic and therapeutic side. Early in my career there was an explosion of activity in this area. Much of it had to do with internal medicine. There were computerized programs that were designed to assist physician decision-making. There were also entire courses taught at the CME level by experts in the field. At the time those experts included Jerome Kassirer, Stephen Pauker, Harold Sox, Richard Kopelman, Alvan Feinstein, and others.  The New England Journal of Medicine has a long-standing feature entitled Case Records of the Massachusetts General Hospital that showcases both diagnostic reasoning and the associated clinicopathological correlates. They added additional articles and a long standing feature on diagnostic decision making. After studying the subject area for about 10 years, I started to teach my own version to 3rd and 4th year medical students. It was focused on not mistaking a medical disorder for a psychiatric one.  It included a complete review of cognitive errors in that setting and how to prevent them. I taught that course for about 10 years.

There are a lot of ideas about psychiatrists and how they may or may not diagnose and treat medical disorders. Systematic biases affect the administrative and environmental systems where psychiatrists work.  Many psychiatrists are very comfortable at the interface of internal medicine or neurology and psychiatry. The most common bias about psychiatrists is that other medical conditions need to be “ruled out” before the patient is referred to a psychiatrist. From a psychiatric perspective the real day-to-day problems include inadequate assessment due to an inability to communicate with the patient and considerable medical comorbidity. Psychiatrists who work in those problem areas need to be competent in recognizing new medical diagnoses and making sure that their prescribed treatment does not adversely affect a person with pre-existing medical disorder.

Against that backdrop I decided to read 2 relatively new books. Both of them have the same title “How Doctors Think”. One book was written by Jerome Groopman, MD hematologist-oncologist by clinical specialty. The other book is written by Kathyrn Montgomery, PhD – a professor of Bioethics, Humanities, and Medicine. As might be expected from the writers’ qualifications Groopman is writing more from the standard perspective of a physician with an intense interest in medical decision making and Montgomery is describing the clinical process and analyzing it from the unique perspective of philosophy and the humanities. It follows that even though the titles are the same these are two very different books.

Groopman’s approach is to use a case-based style of looking at medical decision-making from the perspective of several clinicians-including his own work. The mistakes that occur are teaching moments and are explained from the perspective of heuristics or common cognitive biases. It is the approach I used in my course on preventing cognitive errors associated with psychiatric diagnoses. To cite one example, he describes an athletic forest ranger in his forties. The kind of a guy an internist might say: “I am not worried about his heart – he does his own stress test every day.”  He noticed increasing chest discomfort for a few days without any associated cardiopulmonary symptoms. He presented for an assessment on a day when the pain did not go away. He was seen and thoroughly examined.  There were no physical symptoms, exam findings, or laboratory finding to suggest a cardiac problem and he was released from the emergency department.  He returned a few days later with a myocardial infarction.  Discussions with the attending physician indicate that there were two issues associated with the missed diagnosis of cardiac chest pain – the generally healthy appearance of the patient and a lack of any positive tests indicating coronary artery disease.  Groopman discusses it from the perspective of representativeness bias (p 44) or being affected by a prototype – in this case the patient’s apparent level of fitness and attributing the chest pain to musculoskeletal pain rather than pain of cardiac origin. 

This case also allowed for a discussion of attribution errors especially if the patient fits a negative stereotype.  In the next case, a 70 yr old patient with alcohol use presents with and enlarged nodular liver on exam.  The presumptive diagnosis is alcoholic cirrhosis and the team’s plan was to discharge him back home as soon as possible. Closer examination confirmed that the patient was not drinking that much and searching for other causes of liver disease resulted in a diagnosis of Wilson’s disease.  For most of the book, Groopman uses this technique to illustrate substantial errors, the kind of cognitive bias that it reflects, and corrective action. The reality of “making mistakes on living people” comes though.

He recognized the importance of pattern matching and pattern recognition in clinical practice. There is an initial conversation with a physician that collapses pattern recognition to stereotypes and their associated shortcomings.  He elaborates on the concept and quotes a cognitive scientist to illustrate that pattern recognition may not require any conscious reasoning at all.  An expert can arrive at a diagnosis in about 20 seconds that may take a medical student or resident 30 minutes. Experts begin collecting information about the patient on contact and are immediately considering diagnostic possibilities. I have personally had this experience many times, typically for acute neurological syndromes (strokes, cerebral edema, encephalitis, meningitis) in patients who were referred for me to see in a hospital setting. Pattern matching clearly occurs in the diagnostic process, but it is more difficult to write about and discuss than verbal reasoning.

A major strength of the book is a fairly detailed look at uncertainty in medicine. The diagnoses are not etched in stone and no outcomes are guaranteed based on the accuracy of the diagnosis or not. He introduces a pediatric cardiologist who advances the argument that most of his cases are novel and that there are no set guidelines for what he treats. Even more complicated is that fact that what may appear to be sound science-based treatments like closing an atrial septal defect with a 2:1 shunt in kids it can be an illusion.  Many of those children do well without the surgery and many have had unnecessary surgery. The cardiologist also points out that study of this kind of problem is impossible because of the length of time it would take to do a randomized study.

Another major strength is advice to patients about how to keep the doctor they are seeing thinking about their case.  Numerous examples are given ranging from seeing large number of healthy patients where abnormalities are rare to seeing patients with real problems who have been stereotyped for one reason or another. Groopman is very specific in coaching prospective patients in how to overcome some of the associated biases.  This advice centers on the fact that biological systems are complex and don’t necessarily support logical deductions.  The astute doctor needs to be systematic, evaluate the data for themselves including the elicitation or more history, and question their first impressions. The patient aware of these limitations can ask the correct questions along the way to assist their physician in staying on track. He advises the patient to express their concern about the worst-case scenario to get that out there for discussion and to keep their doctor focused.  The patient is informed of how their history, review of systems and exam may need to be repeated along with some tests that have been previously done. The physician may have to ignore common aphorisms or maxims that are designed to focus on common problems and consider the complex – like more than one diagnosis being suggested. Business management of the medical encounter is seen to impair and obstruct this interactive process.

Groopman’s book is very good both as a guide to patients and a review for physicians who have been educated in diagnostic thinking. In the body of the book technical jargon is avoided and the case scenarios thoroughly explained. There is an excellent list of references and annotations for each chapter at the end of the book. 

How Doctors Think by Kathryn Montgomery takes the unexpected form of a philosophical argument against medicine as a science. She qualifies her criticism by being very clear that she is considering Newtonian or positivist science and not biological science. She recognizes several features of biological science that make it an integral part of medicine, but also not at all like the criteria for science that she sets as the premise for her argument. This is problematic at two levels. First, deterministic and reductionist physicists like Sabine Hossenfelder are very clear that everything is reducible to known subatomic particles and that particles in a brain are deterministic.

“Biology can be reduced to chemistry, chemistry can be reduced to atomic physics, and atoms are made of elementary particles like electrons, quarks, and gluons.” (5)

So for at least some scientists – reductionism is not a problem and the boundaries are not very clear between physical science, biology, and medicine.  Second, it is now known that biological organisms have a wide array of stochastic mechanisms that by virtue of their own nature produce apparently random results. With that range of possibilities, it is not very clear if the standards of physical science are that much different than the biological science necessary for medicine.

Montgomery makes the argument about science and the damage that the idea of medicine as science does to both medicine and its practitioners at several levels.  First, she describes science in medical training. Medical students encounter the basic science curriculum in the first two years of medical school. It is not physical science but biological sciences relevant to understanding pathophysiology, pharmacology, and epidemiology/evidence-based medicine.  She suggests this exposure to science is less relevant as the student transitions to a clinician with adequate clinical judgment – almost to the point that the basic science is an afterthought. This aspect of training is also used to point out that medical students are not being trained as scientists and the remainder of their formal education is spent learning clinical judgement.  At places she describes the preclinical years as fairly bleak period of memorization peripherally related to clinical development.  Second, the uncertainty of biology and medicine is part of her argument.  She extends the argument from the patient side to the side of the doctor. Patients want and need certainty and therefore they want doctors who are schooled in the best possible science who can provide it. Patients want an answer and all they get is statistics. Third, she suggests that the moral and habitual practice of medicine although dependent on human biology and the associated technical advances is not really science.  Physicians are taught to practice medicine and the don’t question “the status of its knowledge” (p. 191). She describes medical practice as a set of rational procedures that are shared with many other professions in the humanities and social sciences.  Fourth, the notion of medicine as a science is “clinically useful” in that it reassures the patients that physicians are engaged in a rational process like they were taught in science classes rather than a contextual, interpretive, narrative process used by non-scientists.  She cites numerous examples of maxims and aphorisms used in medicine to guide this process like Peabody’s famous: “The secret of the care of the patient is in caring for the patient.” 

 Montgomery’s writing is as sophisticated as you might expect from a bioethics professor with a doctorate in English and extensive exposure to medical training. Her critique depends a lot on verbal reasoning and the application of that model to numerous disciplines. Philosophical critiques of medicine and psychiatry that I have responded to in the past are typically presented as arguments with the premises being set by the author. As I read through these arguments being repeated across chapters there were clear points of disagreement.  Here is a short list:

1:  The argument about medicine not being a physical science – that is a good starting point if you want to be able to attack the scientific aspects of medicine, but does anyone really accept that premise? No physical science is taught in the basic science years of medicine.  The basic sciences are focused on human anatomy and physiology. An associated argument is that biological sciences have no overriding laws like physics and that is given as further evidence that medicine is not a science. There is an entire range of science within the basic science of medicine that cannot be explained by physical science but it is necessary for clinical medicine and innovation in medicine.  Finally science is a process that is subject to ongoing verification. That is as true for biological science as it is for physical sciences. While there appear to not be as many absolutes for biology progress is undeniable even within the boundaries of medicine.

2:  Uncertainty in biological systems and medicine - the author makes it seem like defining medicine as a science gives the false impression of certainty. I don’t think that certainty is misrepresented or minimized in clinical medicine.  Every physician I know experiences the uncertainty during informed consent and prognosis discussions. It is built into surgical consent forms and in situations involving medical treatment or testing – the discussions are even more complex. In a typical day, I will advise patients on side effects that occur at rates varying from 4 out of 10 patients to 1 out of 50,000 and tell them what to look for and when to call me.  I have had patients tell me after those discussions that they would prefer not to take a medication or do the recommended testing. I will also discuss life threatening problems with patients, and let them know I cannot predict outcomes but can advise them on how to reduce risk. The only way medicine can practiced is by having appropriate informed consent discussions that fully acknowledge uncertainty and the associated biological heterogeneity.  From the patient side, everyone has a friend, acquaintance, or family member who was healthy until the day there were not. The uncertainty of physical health and medical outcomes at that point are widely known by the general public.

An additional and lesser known aspect of the effect of uncertainty on physician behavior is encouraging the correct answer or treatment as soon as possible. Montgomery attributes some of this to the moral dimension of the physician-patient relationship and doing the right thing for the patient.  But a critical part of uncertainty is that physicians eventually learn to project their decisions out into the future. Those projections are all taken into account in developing the current treatment plan. The outcome of an idealized plan can be viewed as the direct result of the uncertainties involved.  

3:  Physician detachment is a likely consequence of characterizing medicine as a science – At points Montgomery makes the point that physician can emotionally protect themselves by assuming the detached rationality of science. It follows that abandoning medicine as a science would result in a more realistic emotional connection with patients. She has a detailed discussion of the physician-patient relationship being more as a friend or a neighbor.  She concludes that neighborliness has a number of virtues to recommend it as the relationship for the 21st century. Two concepts from psychiatry are omitted from this discussion – empathy and boundaries. Empathy is a technical skill that is typically taught to physicians in their first interviewing courses in the first year of medical school.  It is a technical skill that allows for a more complete understanding of the patient’s emotional and cognitive predicament. In my experience what patients are looking for is a physician who understands them. That is generally not available from a friend or neighbor.  The basic boundary issue is that it is very difficult to provide care to a person who is emotionally involved with the physician. There are degrees of involvement, but any degree is important. A physician who is empathic, had a clear awareness of the relevant boundaries, and has a solid alliance with the patient is far from detached.  But I would not see them as neighborly or a friend.  The physicians job is the be in a position where they can provide the best possible medical advice. That can only happens from a neutral position where they can give a patient the same advice they would give anybody else.  That also does not mean that physicians are not emotionally affect when bad things happen to their patients or when their patients die.

4:  Do ancient Greek concepts still apply? – The author uses Aristotelian definitions of episteme and phronesis several times throughout the text. Episteme is scientific reasoning and phronesis is practical reasoning.  Aristotle’s view was that since there are no “fixed and invariable answers” to questions about health, every question must be considered an individual case.  In those cases, practical reasoning that considers context and additional factors or phronesis applies.  That allows the author to compare medicine to a number of social science disciplines that use the same kind of reasoning.  The question needs to be asked: “What would Aristotle conclude today?”  In ancient Greece there were basically no good medical treatments and medical theory was extremely primitive. Over the intervening centuries medicine has become a lot less imperfect. Uncertainty clearly exists, but the scientific advances are undeniable.  It is possible to say today that there are now fixed and invariable answers to large populations of people. Medicine has always been a collection of probability statements – but those probabilities in terms of successful outcomes have significantly improved.  One the corollaries of  Aristotle’s work is that there can be “no science of individuals” and yet the current goal is individualized or personalized medicine.

5:  Is science relevant to clinicians on a day-to-day basis? -  I think that it is.  I have certainly spent hours and even entire weekends researching patient related problems to find the best solution to a problem and to be absolutely sure that my recommended course of treatment would not harm the patient. All of that reading was basic or clinical science.  On the same day that I received Montgomery’s book, I got my weekly copy of the New England Journal of Medicine.  I have been a subscriber since my first year of medical school based on the recommendation of my biochemistry professor. Our biochemistry class was designed around research seminars where we read and critiqued basic science research. There was also the assumption that you were reading the text cover to cover and attending all of the lectures.  He encouraged all of us to keep up on the science of medicine by continuing to read the NEJM and in retrospect it was a great idea.  In that edition I turned to the Case records of the MGH (6): An 81-Year-Old Man with Cough, Fever, and Shortness of Breath. It was a detailed discussion by an Internist about the presentation and differential diagnosis of the problem. And there on page 2336 was a diagram of the ventilation perfusion mismatch that occurs with a pulmonary embolism and acute respiratory distress syndrome. I have seen this science at the bedside in many clinical settings.  

The clinical competency of pattern matching, pattern recognition, and pattern completion is left out of Montgomery’s description of how doctors think and it is an important omission.  It is a good example of non-verbal and unconscious reasoning that can be a critical part of the process. The answer to the question: “Is this patient critically ill?” and the triage that follows depends on it.  Pattern matching is also experience dependent with experts in their respective fields being able to more rapidly diagnose and classify problems that physicians who are not experts. Biases affecting verbal reasoning can negatively impact the diagnostic process, but so can the lack of experience in seeing patterns of illness and an inadequate number of cases in a particular specialty.

I consider both of these books to be good reads, especially if you are a physician and have had no exposure to thinking about the diagnostic process.  Both authors have their own ideas about what occurs and there is a lot of overlap. Both authors have the goal of stimulating discussion and analysis of how physicians think and educating the general public about it. Physicians will probably find Groopman a faster and more relatable text. Physicians may find the references and vocabulary used in Montgomery to be less recognizable. I would encourage any physician who is responding to initiatives to change the medical curriculum or critique it to read Montgomery’s book and work through her criticisms.  Both books have excellent references and annotations listed by the chapter for further reading. Non-physicians especially patients who are working with physicians on difficult problems may benefit from Groopman’s tips on how to keep those conversations focused and relevant.  As a psychiatrist who is sensitive to attacks (even philosophical ones) from many places – you may find my criticism of Montgomery’s work to be too rigorous. I tried to keep that criticism down to a level that could be contained in a blog post.  I encourage a reading of her book and formulating your own opinions. It is an excellent scholarly work.

Finally, the area of expertise in medicine and the associated clinical judgment of experts is still a current research topic.  The research has gone from basic experiments about who can properly diagnose a rash or diabetic retinopathy to a clear look at brain systems responding during that process. Those changes have occurred over the past 30 years. At the descriptive level it remains important to be aware of the possible cognitive biases and what can be done to overcome them.

 

George Dawson, MD, DFAPA

 

References:

1:  Groopman J.  How Doctors Think. Houghton Mifflin Company, New York, 2008.

2:  Montgomery K.  How Doctors Think. Oxford University Press, New York, 2006.

3:  Kassirer JP, Kopelman RI.  Learning Clinical Reasoning. Williams and Wilkens, Baltimore, 1991.

4:  Sox HC, Blat MA, Higgins MC, Marton KI.  Medical Decision Making. Butterworths, Boston, 1988.

5:  Hossenfelder S.  The End of Reductionism Could Be Nigh. Or Not.  Nautilus June 18,2021 (accessed on June 18, 2021) https://nautil.us/blog/the-end-of-reductionism-could-be-nigh-or-not

6:  Hibbert KA, Goiffon RJ, Fogerty AE. Case 18-2021: An 81-Year-Old Man with Cough, Fever, and Shortness of Breath. N Engl J Med. 2021 Jun 17;384(24):2332-2340. doi: 10.1056/NEJMcpc2100283. PMID: 34133863.