An MGH Case For Acute Care Psychiatrists

 

I have been a New England Journal of Medicine (NEJM) subscriber since I left medical school.  It was a recommended practice in my first year Biochemistry class by the distinguished professors in that class. We had very close contact with them in my medical school for two reasons – daily seminars where we discussed research papers in the applicable topics and their graduate students talking the same course.  It was one of the more intellectually stimulating courses in medical school.   

Over the subsequent 43 years of subscribing, I have noticed a couple of trends.  The most significant one is that psychiatry has been increasingly represented on the pages especially in the past 10-15 years. It is more likely that authors and discussants in the weekly case presentations will be psychiatrists.  You can also get updates on relevant psychiatric papers sent by email. If you scan the table of contents each week it is likely that 2 or 3 papers will be relevant to psychiatric practice – more if you are a neuropsychiatrist or medical psychiatrist.

That brings me to Case 22-2025 from the July 25, 2025 issue.  I will describe the case as briefly as possible due to copyright considerations and the fact you can read all the details in your medical library copy or access.  I want to focus on the diagnostic process and what it implies for both psychiatric diagnosis and treatment.  I also want to focus on the fact that there are acute care psychiatrists in intensely medical settings and they are very knowledgeable and take care of very tough problems that nobody else does.  That can get lost on an almost daily basis as you see provocative headlines and social media posts seeking attention by distorting what psychiatrists do and what they are capable of.

The patient is a 19-year-old woman admitted with episodic right arm and leg shaking and unusual behavior.  The symptoms developed over the 10 days prior to admission with episodic shaking and numbness of the right arm, and slowed speech. A week before admission she collapsed in public and full body shaking was observed.  In the emergency department she was noted to be drooling, confused, and had bitten her tongue.  She gradually became more alert.  In the MGH ED her exam was normal and the only remarkable lab finding was an elevated lactate.  CT and MRI of the brain were normal.  An EEG was normal.  On day 1 she had sudden onset of intense fear and dread followed by whole body shaking lasting 1-1 ½ minutes.  With the last episode she had a decreased oxygen saturation to 50%.  She was started on lorazepam and levetiracetam.  On day 2 she was started on lamotrigine. She was also seen by a psychiatrist and was noted to have extension and stiffening of the right arm, flexion and stiffening of the left arm, turning the head to the right and whole-body stiffening. The episode lasted a minute and she described feeling like “brain and mind were disconnected”. She denied hallucinations, suicidal ideation, and aggressive ideation but did not think that she could return to college.  She became more agitated, tried to run out of her room, and thought the staff were trying to kill her.  She became agitated and required physical restraint and IM olanzapine.

Additional history was remarkable for a grandfather with schizophrenia and past treatment for anxiety and depression – most recently with psychotherapy and no medication.  Following a recent discharge from another hospital and a 5-day admission she was taking levetiracetam, lamotrigine, melatonin, and folic acid. She was rehospitalized after she developed symptoms on the way home from that hospitalization.

This is a severe and acute problem that every acute care psychiatrist should be able to analyze and treat.  The patient exhibits seizure like activity, catatonia, and psychosis in the form of disorganized behavior rather than any descriptions of hallucinations or delusions.  The concern about hospital staff trying to kill her could be paranoia – but unless there is corroboration that it was present for some time – it can also be due to the significant cognitive problems of poor memory and inattentiveness. 

In the subsequent discussion and unfolding events – Judith A. Restrepo, MD – a C-L psychiatrist at MGH presents a refined approach to the problem as outlined in the graphic at the top of this post.  After describing the observed characteristics of the three syndromes on the left she looks at groups of disorders that may account for the syndromes and how common they are.  Since the emergency screening has already been done, she can rule out any associated with obvious abnormalities of brain imaging studies or lab tests.  She goes through each major category and states why a diagnosis is likely of not.  For example, in the Rare Disorders Where Psychotic Sx Are Typical she mentions acute intermittent porphyria and Creutzfeldt-Jakob disease and how they are unlikely due to the illness pattern, lack of GI sx, and a normal EEG. 

In that same category, Dr. Restrepo discusses autoimmune encephalitis as a possibility and eventually lands on that diagnosis.  In the subsequent evaluation (anti-NMDA receptor antibodies, CSF studies, abdominal ultrasound and CT) the diagnosis of anti-NMDA receptor encephalitis secondary to a malignant mixed germ cell tumor of the left ovary was noted.

The case report is useful to read in full because of the complicated post diagnostic course and description of what is known about the treatment of this condition.  I am going to focus on a couple of additional diagnostic issues and the implications for psychiatrists.

Pattern matching remains a critical aspect of all medical diagnoses and that includes psychiatry.  It is still a popular trope that psychiatric diagnosis is DSM centric and nothing could be farther from the truth. The real value of psychiatry is the training and direct observation and assessment of real problems. Reading a checklist of symptoms is essentially worthless without knowing those patterns.  The obvious examples from this case are psychosis, seizures, and catatonia and their many variations.  The wording in the case report is often stacked to cause an association to those patterns.

An obvious example is whole body shaking followed by hypoxemia and an elevated lactate level should lead to an association to generalized seizures and probably similar patients seen in the past with that condition.  Similarly, the features of catatonia should be obvious without referring to a catatonia rating scale and lead to associations to past catatonia patients diagnosed and treated. Superimposed on these diagnostic patterns should be a general pattern of how to approach very ill patients – in this case patients who have either serious psychiatric disorders or psychiatric syndromes secondary to serious medical and neurological conditions. How should a stuporous or comatose patient be examined (2)?   In this specific patient could the arm movements be decorticate or decerebrate posturing?   Could they be a movement disorder?  That should include a triage pattern of how that patient needs to be stabilized until the diagnosis is determined.

As an example – what should happen if this patient is described to you as an admitting psychiatrist?  Should they be admitted to a typical inpatient psychiatric unit?  All that I would need to hear is hypoxemia following seizure like activity and my answer would be no.  They need to be in a unit that has telemetry and critical care nursing and psychiatric units do not.

There are also patterns on the rule-in side.  Are there any features of this illness that match typical patterns of schizophrenia, bipolar disorder, or depression?  Are there any features that match acute intoxication with commonly used substances?  Is the patient medically stable enough to be treated on a psychiatric unit? 

How do we prepare acute care psychiatrists who are based in medical neuroscience?  Thomas Insel the former NIMH director had the idea of a rotating clinical neuroscience fellowship where neurology, psychiatry, and neurosurgery residents would do a 2 year fellowship before moving on their respective residencies.  That is a hard sell when you come out of it needing to do another 3 – 5 years of residency. 

I propose getting ready in medical school.  Most MS4 courses are electives and there is probably room to further modify the MS3 year.  In addition to basic general medicine and surgery I recommend the following electives: neurosurgery, neurology, endocrinology, infectious disease, renal medicine, cardiology, emergency medicine, and allergy and immunology.  Just rotating through is not enough given what I have said about the pattern matching requirement.  As many acute care cases and unusual presentations of psychiatric disorders associated with brain and medical illnesses need to be seen as possible.  Only that will get residents ready to make diagnoses like the one in this case. It helps to have an attitude and interest in treating the most severe problems in psychiatry. 

And once you are out – keep reading the journals including the NEJM.

 

George Dawson, MD, DFAPA

  

Supplementary 1:  Thought I would add a couple of supplementary comments here rather than adding them to the main post.

Psychiatry is not DSM centric:  Practically every critic of the field and by default these days every social media venue and many journals have lengthy debates about the DSM, what it does or not do, and how it affects the future of psychiatry.  The above post is a shining example of what I did in over 35 years of practice.  At no point in that 35 years did I pull the old DSM off the shelf and think: “Gee I wonder what the DSM will tell me to diagnose?”  Just today I was in a seminar where the question was: “What diagnosis should we use for psychotherapy?” and reminded that the primary use of the DSM and why it was invented – initially for statistical and census purposes and now for billing and coding.  In other words, today – you do not get paid if you don’t have a diagnostic code but that code is technically an ICD-10 code and not a DSM code.

Should that role lead to protracted debates in journals and social media.  I guess I will take the lead role is saying emphatically no.  You can take all the debates about the precision and validity of psychiatric diagnoses and watch it explode in this case report. We see real psychiatry in action.  A psychiatry where patterns of illness are recognized and critical in making a diagnosis of a life-threatening condition.

Pathology in a psychiatric case:  I did not mention that this case report contains a pathology report including photos of the gross pathology and microscopic pathology of the left ovarian mass and the malignant germ cell tumor. This is reminiscent of late 19^th/early 20^th century psychiatry looking for neuropathological autopsy correlates of severe mental illness and the famous psychiatrists involved. It was a more intellectually stimulating approach and there were results but not for the major psychiatric disorders leading to asylum care at the time namely bipolar disorder, schizophrenia, and depression/melancholia. Now that the pathology is more specific should psychiatrists be taught the pathology and the pathophysiology of these disorders?  Should they be aware of all paraneoplastic syndromes that cause psychiatric symptomatology.  Of course they should. It is more important than a DSM and unless the DSM is serious about including real patterns and pathology it will be much less relevant in the future.  We have reached a limit when it comes to parsing words about psychiatric diagnoses and need to get back to reality.    

References:   

1:  Restrepo JA, Mojtahed A, Morelli LW, Venna N, Turashvili G. Case 22-2025: A 19-Year-Old Woman with Seizure like Activity and Odd Behaviors. N Engl J Med. 2025 Jul 31;393(5):488-496. doi: 10.1056/NEJMcpc2412531. PMID: 40742263.

2:  Plum F, Posner JB.  The Diagnosis of Stupor and Coma.  FA Davis Company, Philadelphia, 1980.